TY - JOUR
T1 - Revisiting demographic processes in cattle with genome-wide population genetic analysis
AU - Orozco-Terwengel, Pablo
AU - Barbato, Mario
AU - Nicolazzi, Ezequiel
AU - Biscarini, Filippo
AU - Milanesi, Marco
AU - Davies, Wyn
AU - Williams, Don
AU - Stella, Alessandra
AU - Ajmone Marsan, Paolo
AU - Bruford, Michael W.
PY - 2015
Y1 - 2015
N2 - The domestication of the aurochs took place approximately 10,000 years ago giving rise to the two main types of domestic cattle known today, taurine (Bos taurus) domesticated somewhere on or near the Fertile Crescent, and indicine (Bos indicus) domesticated in the Indus Valley. However, although cattle have historically played a prominent role in human society the exact origin of many extant breeds is not well known. Here we used a combination of medium and high-density Illumina Bovine SNP arrays (i.e., similar to 54,000 and similar to 770,000 SNPs, respectively), genotyped for over 1300 animals representing 56 cattle breeds, to describe the relationships among major European cattle breeds and detect patterns of admixture among them. Our results suggest modern cross-breeding and ancient hybridisation events have both played an important role, including with animals of indicine origin. We use these data to identify signatures of selection reflecting both domestication (hypothesized to produce a common signature across breeds) and local adaptation (predicted to exhibit a signature of selection unique to a single breed or group of related breeds with a common history) to uncover additional demographic complexity of modern European cattle.
AB - The domestication of the aurochs took place approximately 10,000 years ago giving rise to the two main types of domestic cattle known today, taurine (Bos taurus) domesticated somewhere on or near the Fertile Crescent, and indicine (Bos indicus) domesticated in the Indus Valley. However, although cattle have historically played a prominent role in human society the exact origin of many extant breeds is not well known. Here we used a combination of medium and high-density Illumina Bovine SNP arrays (i.e., similar to 54,000 and similar to 770,000 SNPs, respectively), genotyped for over 1300 animals representing 56 cattle breeds, to describe the relationships among major European cattle breeds and detect patterns of admixture among them. Our results suggest modern cross-breeding and ancient hybridisation events have both played an important role, including with animals of indicine origin. We use these data to identify signatures of selection reflecting both domestication (hypothesized to produce a common signature across breeds) and local adaptation (predicted to exhibit a signature of selection unique to a single breed or group of related breeds with a common history) to uncover additional demographic complexity of modern European cattle.
KW - genome-wide
KW - population genetic analysis
KW - genome-wide
KW - population genetic analysis
UR - http://hdl.handle.net/10807/69027
U2 - 10.3389/fgene.2015.00191
DO - 10.3389/fgene.2015.00191
M3 - Article
SN - 1664-8021
VL - 6
SP - N/A-N/A
JO - Frontiers in Genetics
JF - Frontiers in Genetics
ER -