Revised upper limb module for spinal muscular atrophy: 12 month changes

Marika Pane, Eugenio Maria Mercuri, Maria Carmela Pera, Giorgia Coratti, Roberto De Sanctis, Jacqueline Montes, Mariacristina Scoto, Marion Main, Anna Mayhew, Robert Muni Lofra, Sally Dunaway Young, Allan M. Glanzman, Tina Duong, Amy Pasternak, Danielle Ramsey, Basil Darras, John W. Day, Richard S. Finkel, Darryl C. De Vivo, Maria Pia SormaniFrancesca Bovis, Volker Straub, Francesco Muntoni

Research output: Contribution to journalArticle

19 Citations (Scopus)


Abstract INTRODUCTION: The aim of the study was to assess 12 month changes in upper limb function in patients affected by spinal muscular atrophy type 2 and 3. METHODS: Longitudinal 12 month data was collected in 114 patients, 60 type 2 and 54 type 3, using the Revised Upper Limb Module. RESULTS: The 12 month changes ranged between -7 and 9 (mean: -0.41; SD: 2.93). The mean changes were not significantly different between the three spinal muscular atrophy groups (-0.45 in type 2, -0.23 in non-ambulant type 3 and -0.34 in ambulant type 3, p = 0.96) and the relationship between 12 month change and age classes was not significantly different among the three types of SMA patients. DISCUSSION: Our results confirm that the Module explores a wide range of functional abilities and can be used in ambulant and non-ambulant patients of different ages in conjunction with other functional scales. Muscle Nerve 59:426-430, 2019. © 2019 Wiley Periodicals, Inc. KEYWORDS: Functional assessment; Longitudinal Data; Neuromuscular disorders; Outcome measures; Spinal Muscular Atrophy; Upper limb
Original languageEnglish
Pages (from-to)426-430
Number of pages5
Publication statusPublished - 2019




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