Retroperitoneal soft tissue sarcoma: prognostic factors and therapeutic approaches

Fabio Pacelli, Fausto Rosa, Valerio Papa, Maurizio Bossola, Marcello Covino, Antonio Pio Tortorelli, Alejandro Martin Sanchez, Roberta Menghi, Giovanni Doglietto, Alessandra Ferro

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

AIMS AND BACKGROUND: Retroperitoneal sarcomas are a rare group of malignant soft tissue tumors with a generally poor prognosis. The aim of the study was to assess clinical, pathological and treatment-related factors affecting prognosis in patients with retroperitoneal sarcomas. METHODS AND STUDY DESIGN: The hospital records of 73 patients who underwent surgical exploration at our unit for primary retroperitoneal sarcomas between 1984 and 2003 were reviewed. Factors influencing overall and disease-free survival were analyzed for all patients and for those who underwent complete surgical resection. RESULTS: The complete resectability rate was 69.8% (51/73). Operative mortality and morbidity rates were 2.7% and 21.9%, respectively. For patients who underwent complete resection, the 5-year survival rate was 58.3%, whereas it was 0% in cases of incomplete or no resection (P < 0.001). Local recurrence rate was 37.2%. Incomplete gross surgical resection and microscopic infiltration of margins were the most important independent predictors of a poor prognosis. CONCLUSIONS: The present study confirmed the importance of an aggressive surgical management for retroperitoneal sarcomas to offer these patients the best chance for long-term survival.
Original languageEnglish
Pages (from-to)497-504
Number of pages8
JournalTumori
Publication statusPublished - 2008

Keywords

  • Retroperitoneal sarcoma

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