Retinoic acid and arsenic trioxide for acute promyelocytic leukemia

F Lo Coco; G Avvisati; M Vignetti; C Thiede; Sm Orlando; S Iacobelli; F Ferrara; P Fazi; L Cicconi; E Di Bona; G Specchia; Simona Sica; M Divona; A Levis; W Fiedler; E Cerqui; M Breccia; G Fioritoni; Hr Salih; M Cazzola; L Melillo; Am Carella; Ch Brandts; E Morra; M Von Lilienfeld Toal; B Hertenstein; M Wattad; M Lübbert; M Hänel; N Schmitz; H Link; Mg Kropp; A Rambaldi; G La Nasa; M Luppi; F Ciceri; O Finizio; A Venditti; F Fabbiano; K Döhner; M Sauer; A Ganser; S Amadori; F Mandelli; H Döhner; G Ehninger; Rf Schlenk; U. Platzbecker

doi:10.1056/NEJMoa1300874

Retinoic acid and arsenic trioxide for acute promyelocytic leukemia

F Lo Coco
, G Avvisati
, M Vignetti
, C Thiede
, Sm Orlando
, S Iacobelli
, F Ferrara
, P Fazi
, L Cicconi
, E Di Bona
, G Specchia
, Simona Sica
, M Divona
, A Levis
, W Fiedler
, E Cerqui
, M Breccia
, G Fioritoni
, Hr Salih
, M Cazzola

L Melillo, Am Carella, Ch Brandts, E Morra, M Von Lilienfeld Toal, B Hertenstein, M Wattad, M Lübbert, M Hänel, N Schmitz, H Link, Mg Kropp, A Rambaldi, G La Nasa, M Luppi, F Ciceri, O Finizio, A Venditti, F Fabbiano, K Döhner, M Sauer, A Ganser, S Amadori, F Mandelli, H Döhner, G Ehninger, Rf Schlenk, U. Platzbecker

Technische Universität Dresden (TU Dresden)

Research output: Contribution to journal › Article

819 Citations (Scopus)

Abstract

All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL), resulting in cure rates exceeding 80%. Pilot studies of treatment with arsenic trioxide with or without ATRA have shown high efficacy and reduced hematologic toxicity.

Original language	English
Pages (from-to)	111-121
Number of pages	11
Journal	New England Journal of Medicine
Volume	369
Issue number	2
DOIs	https://doi.org/10.1056/NEJMoa1300874
Publication status	Published - 2013

All Science Journal Classification (ASJC) codes

General Medicine

Keywords

Acute
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Arsenicals
Consolidation Chemotherapy
Disease-Free Survival
Female
Humans
Induction Chemotherapy
Leukemia
Maintenance Chemotherapy
Male
Middle Aged
Neutropenia
Oxides
Promyelocytic
Thrombocytopenia
Tretinoin
Young Adult

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10.1056/NEJMoa1300874

Cite this

Lo Coco, F., Avvisati, G., Vignetti, M., Thiede, C., Orlando, S., Iacobelli, S., Ferrara, F., Fazi, P., Cicconi, L., Di Bona, E., Specchia, G., Sica, S., Divona, M., Levis, A., Fiedler, W., Cerqui, E., Breccia, M., Fioritoni, G., Salih, H., ... Platzbecker, U. (2013). Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. New England Journal of Medicine, 369(2), 111-121. https://doi.org/10.1056/NEJMoa1300874

@article{18a43b964e0b4c4d8c3f518846fb3bee,

title = "Retinoic acid and arsenic trioxide for acute promyelocytic leukemia",

abstract = "All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL), resulting in cure rates exceeding 80\%. Pilot studies of treatment with arsenic trioxide with or without ATRA have shown high efficacy and reduced hematologic toxicity.",

keywords = "Acute, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Arsenicals, Consolidation Chemotherapy, Disease-Free Survival, Female, Humans, Induction Chemotherapy, Leukemia, Maintenance Chemotherapy, Male, Middle Aged, Neutropenia, Oxides, Promyelocytic, Thrombocytopenia, Tretinoin, Young Adult, Acute, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Arsenicals, Consolidation Chemotherapy, Disease-Free Survival, Female, Humans, Induction Chemotherapy, Leukemia, Maintenance Chemotherapy, Male, Middle Aged, Neutropenia, Oxides, Promyelocytic, Thrombocytopenia, Tretinoin, Young Adult",

author = "\{Lo Coco\}, F and G Avvisati and M Vignetti and C Thiede and Sm Orlando and S Iacobelli and F Ferrara and P Fazi and L Cicconi and \{Di Bona\}, E and G Specchia and Simona Sica and M Divona and A Levis and W Fiedler and E Cerqui and M Breccia and G Fioritoni and Hr Salih and M Cazzola and L Melillo and Am Carella and Ch Brandts and E Morra and \{Von Lilienfeld Toal\}, M and B Hertenstein and M Wattad and M L{\"u}bbert and M H{\"a}nel and N Schmitz and H Link and Mg Kropp and A Rambaldi and \{La Nasa\}, G and M Luppi and F Ciceri and O Finizio and A Venditti and F Fabbiano and K D{\"o}hner and M Sauer and A Ganser and S Amadori and F Mandelli and H D{\"o}hner and G Ehninger and Rf Schlenk and U. Platzbecker",

year = "2013",

doi = "10.1056/NEJMoa1300874",

language = "English",

volume = "369",

pages = "111--121",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

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}

Lo Coco, F, Avvisati, G, Vignetti, M, Thiede, C, Orlando, S, Iacobelli, S, Ferrara, F, Fazi, P, Cicconi, L, Di Bona, E, Specchia, G, Sica, S, Divona, M, Levis, A, Fiedler, W, Cerqui, E, Breccia, M, Fioritoni, G, Salih, H, Cazzola, M, Melillo, L, Carella, A, Brandts, C, Morra, E, Von Lilienfeld Toal, M, Hertenstein, B, Wattad, M, Lübbert, M, Hänel, M, Schmitz, N, Link, H, Kropp, M, Rambaldi, A, La Nasa, G, Luppi, M, Ciceri, F, Finizio, O, Venditti, A, Fabbiano, F, Döhner, K, Sauer, M, Ganser, A, Amadori, S, Mandelli, F, Döhner, H, Ehninger, G, Schlenk, R & Platzbecker, U 2013, 'Retinoic acid and arsenic trioxide for acute promyelocytic leukemia', New England Journal of Medicine, vol. 369, no. 2, pp. 111-121. https://doi.org/10.1056/NEJMoa1300874

TY - JOUR

T1 - Retinoic acid and arsenic trioxide for acute promyelocytic leukemia

AU - Lo Coco, F

AU - Avvisati, G

AU - Vignetti, M

AU - Thiede, C

AU - Orlando, Sm

AU - Iacobelli, S

AU - Ferrara, F

AU - Fazi, P

AU - Cicconi, L

AU - Di Bona, E

AU - Specchia, G

AU - Sica, Simona

AU - Divona, M

AU - Levis, A

AU - Fiedler, W

AU - Cerqui, E

AU - Breccia, M

AU - Fioritoni, G

AU - Salih, Hr

AU - Cazzola, M

AU - Melillo, L

AU - Carella, Am

AU - Brandts, Ch

AU - Morra, E

AU - Von Lilienfeld Toal, M

AU - Hertenstein, B

AU - Wattad, M

AU - Lübbert, M

AU - Hänel, M

AU - Schmitz, N

AU - Link, H

AU - Kropp, Mg

AU - Rambaldi, A

AU - La Nasa, G

AU - Luppi, M

AU - Ciceri, F

AU - Finizio, O

AU - Venditti, A

AU - Fabbiano, F

AU - Döhner, K

AU - Sauer, M

AU - Ganser, A

AU - Amadori, S

AU - Mandelli, F

AU - Döhner, H

AU - Ehninger, G

AU - Schlenk, Rf

AU - Platzbecker, U.

PY - 2013

Y1 - 2013

N2 - All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL), resulting in cure rates exceeding 80%. Pilot studies of treatment with arsenic trioxide with or without ATRA have shown high efficacy and reduced hematologic toxicity.

AB - All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL), resulting in cure rates exceeding 80%. Pilot studies of treatment with arsenic trioxide with or without ATRA have shown high efficacy and reduced hematologic toxicity.

KW - Acute

KW - Adult

KW - Aged

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Arsenicals

KW - Consolidation Chemotherapy

KW - Disease-Free Survival

KW - Female

KW - Humans

KW - Induction Chemotherapy

KW - Leukemia

KW - Maintenance Chemotherapy

KW - Male

KW - Middle Aged

KW - Neutropenia

KW - Oxides

KW - Promyelocytic

KW - Thrombocytopenia

KW - Tretinoin

KW - Young Adult

KW - Acute

KW - Adult

KW - Aged

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Arsenicals

KW - Consolidation Chemotherapy

KW - Disease-Free Survival

KW - Female

KW - Humans

KW - Induction Chemotherapy

KW - Leukemia

KW - Maintenance Chemotherapy

KW - Male

KW - Middle Aged

KW - Neutropenia

KW - Oxides

KW - Promyelocytic

KW - Thrombocytopenia

KW - Tretinoin

KW - Young Adult

UR - https://publicatt.unicatt.it/handle/10807/50964

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U2 - 10.1056/NEJMoa1300874

DO - 10.1056/NEJMoa1300874

M3 - Article

SN - 0028-4793

VL - 369

SP - 111

EP - 121

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 2

ER -

Retinoic acid and arsenic trioxide for acute promyelocytic leukemia

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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