Restless Legs Syndrome and lateralized periodic movements due to a spinal schwannoma

Domenico Restuccia, Giacomo Della Marca, Anna Losurdo, Marco Luigetti, Catello Vollono, Elisa Testani, Valentina Gnoni, Chiara Di Blasi

Research output: Contribution to journalArticle


We describe a case of Restless Legs Syndrome (RLS) associated to periodic limb movements (PLMs) in a woman with a cervical schwannoma. Neurological examination, laboratory tests, neurography and electromyography were unremarkable. Neuroimaging evidenced a schwannoma at C3 level that compressed the right ventral surface of the medulla. Somatosensory-evoked potentials showed absence of the N13 after right median nerve stimulation and reduction of amplitude of the same component after left nerve stimulation. A video-polysomnography documented PLMs with a marked prevalence of the right-sided movements. We believe that the cervical schwannoma played a role in the pathogenesis of RLS and of lateralized PLMs.
Original languageEnglish
Pages (from-to)106-108
Number of pages3
JournalSleep and Biological Rhythms
Publication statusPublished - 2015


  • Cervical schwannoma
  • Periodic limb movements
  • Restless Legs Syndrome
  • Somatosensory evoked potentials


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