Response to Letter to the Editor: "incidence of Hypoglycemia after Gastric Bypass vs Sleeve Gastrectomy: A Randomized Trial"

Esmeralda Capristo; Simona Panunzi; Andrea De Gaetano; Valerio Spuntarelli; Rocco Domenico Alfonso Bellantone; Piero Giustacchini; Andreas L Birkenfeld; Stephanie Amiel; Stefan R Bornstein; Marco Raffaelli; Geltrude Mingrone

doi:10.1210/jc.2018-01813

Response to Letter to the Editor: "incidence of Hypoglycemia after Gastric Bypass vs Sleeve Gastrectomy: A Randomized Trial"

Esmeralda Capristo, Simona Panunzi, Andrea De Gaetano, Valerio Spuntarelli, Rocco Domenico Alfonso Bellantone, Piero Giustacchini, Andreas L Birkenfeld, Stephanie Amiel, Stefan R Bornstein, Marco Raffaelli, Geltrude Mingrone

Research output: Contribution to journal › Article

Abstract

First, we would like to clarify that the sample size of our RCT was calculated correctly, based on the relevant data available from reported studies before our RCT began. An incidence of 68% and 20% was reported for RYGB (2) and SG (3), respectively. Therefore, the absolute difference in the occurrence of hypoglycemia between the two surgical procedures was ∼50%. However, we considered a more conservative difference of 30% and calculated that, with two-tailed P < 0.05 and a test power of 0.90, 50 subjects in each group would have been sufficient to meet the criteria for superiority compared with SG treatment. Considering an attrition rate of 20%, the patients enrolled were 120 overall, with 60 in each group.

Original language	English
Pages (from-to)	732-733
Number of pages	2
Journal	THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Volume	104
DOIs	https://doi.org/10.1210/jc.2018-01813
Publication status	Published - 2018

Keywords

Biochemistry
Biochemistry (medical)
Clinical Biochemistry
Endocrinology
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1210/jc.2018-01813

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Capristo, E., Panunzi, S., De Gaetano, A., Spuntarelli, V., Bellantone, R. D. A., Giustacchini, P., Birkenfeld, A. L., Amiel, S., Bornstein, S. R., Raffaelli, M., & Mingrone, G. (2018). Response to Letter to the Editor: "incidence of Hypoglycemia after Gastric Bypass vs Sleeve Gastrectomy: A Randomized Trial". THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 104, 732-733. https://doi.org/10.1210/jc.2018-01813

@article{c3aa10628de64f56aa467bacf75e61c9,

title = "Response to Letter to the Editor: {"}incidence of Hypoglycemia after Gastric Bypass vs Sleeve Gastrectomy: A Randomized Trial{"}",

abstract = "First, we would like to clarify that the sample size of our RCT was calculated correctly, based on the relevant data available from reported studies before our RCT began. An incidence of 68% and 20% was reported for RYGB (2) and SG (3), respectively. Therefore, the absolute difference in the occurrence of hypoglycemia between the two surgical procedures was ∼50%. However, we considered a more conservative difference of 30% and calculated that, with two-tailed P < 0.05 and a test power of 0.90, 50 subjects in each group would have been sufficient to meet the criteria for superiority compared with SG treatment. Considering an attrition rate of 20%, the patients enrolled were 120 overall, with 60 in each group.",

keywords = "Biochemistry, Biochemistry (medical), Clinical Biochemistry, Endocrinology, Endocrinology, Diabetes and Metabolism, Biochemistry, Biochemistry (medical), Clinical Biochemistry, Endocrinology, Endocrinology, Diabetes and Metabolism",

author = "Esmeralda Capristo and Simona Panunzi and {De Gaetano}, Andrea and Valerio Spuntarelli and Bellantone, {Rocco Domenico Alfonso} and Piero Giustacchini and Birkenfeld, {Andreas L} and Stephanie Amiel and Bornstein, {Stefan R} and Marco Raffaelli and Geltrude Mingrone",

year = "2018",

doi = "10.1210/jc.2018-01813",

language = "English",

volume = "104",

pages = "732--733",

journal = "THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM",

issn = "0021-972X",

publisher = "-Springfield, Ill. : Charles C. Thomas -Philadelphia : J.B. Lippincott Co. -Baltimore, Md. : Issued for the Endocrine Society by the Williams & Wilkins Co. -Bethesda, MD : Endocrine Society -Chevy Chase, MD : Endocrine Society",

}

Capristo, E, Panunzi, S, De Gaetano, A, Spuntarelli, V, Bellantone, RDA, Giustacchini, P, Birkenfeld, AL, Amiel, S, Bornstein, SR, Raffaelli, M & Mingrone, G 2018, 'Response to Letter to the Editor: "incidence of Hypoglycemia after Gastric Bypass vs Sleeve Gastrectomy: A Randomized Trial"', THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 104, pp. 732-733. https://doi.org/10.1210/jc.2018-01813

TY - JOUR

T1 - Response to Letter to the Editor: "incidence of Hypoglycemia after Gastric Bypass vs Sleeve Gastrectomy: A Randomized Trial"

AU - Capristo, Esmeralda

AU - Panunzi, Simona

AU - De Gaetano, Andrea

AU - Spuntarelli, Valerio

AU - Bellantone, Rocco Domenico Alfonso

AU - Giustacchini, Piero

AU - Birkenfeld, Andreas L

AU - Amiel, Stephanie

AU - Bornstein, Stefan R

AU - Raffaelli, Marco

AU - Mingrone, Geltrude

PY - 2018

Y1 - 2018

N2 - First, we would like to clarify that the sample size of our RCT was calculated correctly, based on the relevant data available from reported studies before our RCT began. An incidence of 68% and 20% was reported for RYGB (2) and SG (3), respectively. Therefore, the absolute difference in the occurrence of hypoglycemia between the two surgical procedures was ∼50%. However, we considered a more conservative difference of 30% and calculated that, with two-tailed P < 0.05 and a test power of 0.90, 50 subjects in each group would have been sufficient to meet the criteria for superiority compared with SG treatment. Considering an attrition rate of 20%, the patients enrolled were 120 overall, with 60 in each group.

AB - First, we would like to clarify that the sample size of our RCT was calculated correctly, based on the relevant data available from reported studies before our RCT began. An incidence of 68% and 20% was reported for RYGB (2) and SG (3), respectively. Therefore, the absolute difference in the occurrence of hypoglycemia between the two surgical procedures was ∼50%. However, we considered a more conservative difference of 30% and calculated that, with two-tailed P < 0.05 and a test power of 0.90, 50 subjects in each group would have been sufficient to meet the criteria for superiority compared with SG treatment. Considering an attrition rate of 20%, the patients enrolled were 120 overall, with 60 in each group.

KW - Biochemistry

KW - Biochemistry (medical)

KW - Clinical Biochemistry

KW - Endocrinology

KW - Endocrinology, Diabetes and Metabolism

KW - Biochemistry

KW - Biochemistry (medical)

KW - Clinical Biochemistry

KW - Endocrinology

KW - Endocrinology, Diabetes and Metabolism

UR - http://hdl.handle.net/10807/131675

UR - http://jcem.endojournals.org

U2 - 10.1210/jc.2018-01813

DO - 10.1210/jc.2018-01813

M3 - Article

SN - 0021-972X

VL - 104

SP - 732

EP - 733

JO - THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM

JF - THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM

ER -

Response to Letter to the Editor: "incidence of Hypoglycemia after Gastric Bypass vs Sleeve Gastrectomy: A Randomized Trial"

Abstract

Keywords

UN SDGs

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