Resistin regulates human choriocarcinoma cell invasive behaviour and endothelial cell angiogenic process

Maurizio Sanguinetti, Nicoletta Di Simone, Fiorella Di Nicuolo, Roberta Castellani, Marco D'Asta, Leonardo Caforio, Alessandro Caruso

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59 Citations (Scopus)


Resistin is a novel hormone that is secreted by human adipocytes and mononuclear cells and is probably associated with insulin resistance. Recently, resistin has been postulated to play a role in pregnancy, and resistin gene expression has been observed in placental tissues. However, it is still not known if resistin is able to affect trophoblast functions and development. Therefore, we investigated the hypothesis that resistin might regulate trophoblast production of matrix metalloproteinases (MMPs), the tissue inhibitors of metalloproteinases (TIMPs), trophoblast invasive behavior and the angiogenic processes. In human choriocarcinoma cells (BeWo), resistin (10-100 ng/ml) enhanced both MMP-2 protein and mRNA expression, significantly reduced TIMP-1 and TIMP-2 and increased trophoblast-like cell invasiveness. We analyzed the effect of resistin on an in vitro angiogenesis system for endothelial cells (HUVEC) and we evaluated its ability to modulate the secretion of an angiogenic factor, vascular endothelial growth factor (VEGF). Our data showed that resistin induced VEGF production and we observed that the addition of resistin stimulated endothelial cell tube formation. These findings suggest that resistin might be able to induce BeWo cell invasiveness and to contribute to the control of placental vascular development
Original languageEnglish
Pages (from-to)691-699
Number of pages9
JournalJournal of Endocrinology
Publication statusPublished - 2006


  • Resistin
  • angiogensis
  • trophoblast invasiveness


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