Redox factor-1 in muscle biopsies of patients with inclusion-body myositis

Aldobrando Broccolini, W. King Engel, Renate Alvarez, Valerie Askanas

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

To determine whether redox factor-1 (Ref-1) participates in the pathogenesis of inclusion-body myositis (IBM), we immunolocalized Ref-1 in muscle biopsies of IBM patients by light- and electron-microscopy. Approximately 70-80% of the IBM vacuolated muscle fibers had focal inclusions strongly immunoreactive for Ref-1. By immunoelectronmicroscopy, Ref-1 was localized to paired-helical filaments, 6-10 nm amyloid-like fibrils and amorphous material. Virtually all regenerating and necrotic muscle fibers in various muscle biopsies had diffusely strong Ref-1 immunoreactivity. At all neuromuscular junctions, postsynaptically there was strong Ref-1 immunoreactivity. Our study suggests that Ref-1 plays a role in IBM pathogenesis, and in other pathologic and normal processes of human muscle
Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalNeuroscience Letters
Publication statusPublished - 2000

Keywords

  • IBM

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