Recurrent urinary tract infections in kidney transplant recipients during the first-year influence long-term graft function: a single-center retrospective cohort study

Giuseppe Grandaliano, Francesco Pesce, Marida Martino, Marco Fiorentino, Tiziana Rollo, Simona Simone, Pasquale Gallo, Giovanni Stallone, Antonio Schena, Marcella Margiotta, Donata Mininni, Rita Palieri, Giuseppe Lucarelli, Michele Battaglia, Loreto Gesualdo, Giuseppe Castellano

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Urinary tract infections (UTIs) after kidney transplantation are associated with significant morbidity. However, data on the impact of UTI on graft survival are controversial. We conducted a retrospective cohort study of 380 kidney transplant patients. Recipients with symptomatic UTIs during the first year after transplantation were categorized into three groups: early (< 3 episodes from months 1st to 6th), late (< 3 episodes during months 7th to 12th) and recurrent (≥ 3 episodes throughout the whole first year). Graft function at three years was considered the primary outcome. Symptomatic UTIs occurred in 184 (48.4%) kidney transplant recipients during the first year; 83 (21.8%) patients developed early UTIs, 50 (13.2%) late UTIs and 51 (13.4%) recurrent UTIs. We observed a significant improvement in graft function after three years in all patients (P < 0.001) except those who had recurrent UTIs. A Kaplan–Meier analysis showed that recipients with recurrent UTIs had worse graft outcome (eGFR value < 60 mL/min/1.73 m2) (P = 0.01). Recurrent UTIs was an independent predictor of graft function at three years in a model adjusted for DGF and episodes of acute rejection (Hazard Ratio, 2.2; 95% CI, 1.3 to 3.5; P = 0.001). Recurrent symptomatic UTIs during the first year after transplantation have negative impact on long-term graft function.
Original languageEnglish
Pages (from-to)661-668
Number of pages8
JournalJN. JOURNAL OF NEPHROLOGY
Volume32
DOIs
Publication statusPublished - 2019

Keywords

  • Graft function
  • Kidney transplant
  • Urinary tract infections

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