Reconstitution of aluminium and iron core in horse spleen apoferritin

Gabriele Ciasca, M Chiarpotto, G Campi, B Bocca, M Rodio, A Pino, A Ricci, N Poccia, C Rossi, A Alimonti, H Amenitsch, P Sole, A. Bianconi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

This study investigates the uptake of iron and aluminium by apoferritin. In particular, we provide the first evidence that apoferritin is able to bind in vitro the physiological form of aluminium, Al(OH)4 −, to reach an Al/Fe atomic ratio of about 0.15. Mass spectrometry analysis shows that the Al content increases linearly as a function of Al concentration in solution. These findings provide a better understanding of the Al uptake in vivo, confirming that the metal content of ferritin depends on the metal bio-availability.
Original languageEnglish
Pages (from-to)6149-6155
Number of pages7
JournalJournal of Nanoparticle Research
Volume13
DOIs
Publication statusPublished - 2011

Keywords

  • Aluminium Metal toxicity Ferritin SAXS ICP-MS Nanomedicine

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