Recombinant interferon gamma lb and low dose steroid in two pediatric cases of nonspecific interstitial pneumonia

Donato Rigante, Angelica Bibiana Delogu, Gabriella De Rosa, Gilda Federico, Achille Stabile

Research output: Contribution to journalArticlepeer-review

Abstract

We report two young girls, the first almost 18 years old and the second 12 1/2 years old, affected with nonspecific interstitial pneumonia, both diagnosed at the age of 11 by open lung biopsy and both being treated with low-dose steroid. Due to insufficient response to conventional therapy and based on positive therapeutic results following the use of subcutaneous recombinant interferon gamma-1b in fibrosing interstitial pneumonias of adults, they were given a 1-year trial of subcutaneous recombinant interferon gamma-lb in association with a steroid. Our experience with these two young patients suggests that interferon gamma-lb cannot be considered as stabilizing or a curative therapy to control or reverse nonspecific interstitial pneumonia unresponsive to steroids alone.
Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalMount Sinai Journal of Medicine
Volume2004
Publication statusPublished - 2004

Keywords

  • Interferon gamma lb
  • interstitial pneumonia
  • steroid

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