Recognition of DNA sequence by an inorganic crystal surface

Beatrice Sampaolese, Massimo Castagnola, Anna Bergia, Anita Scipioni, Giampaolo Zuccheri, Maria Savino, Bruno Samori, Pasquale De Santis

Research output: Contribution to journalArticle


The sequence-dependent curvature is generally recognized as an important and biologically relevant property of DNA because it is involved in the formation and stability of association complexes with proteins. When a DNA tract, intrinsically curved for the periodical recurrence on the same strand of A-tracts phased with the B-DNA periodicity, is deposited on a flat surface, it exposes to that surface either a T- or an A-rich face. The surface of a freshly cleaved mica crystal recognizes those two faces and preferentially interacts with the former one. Statistical analysis of scanning force microscopy (SFM) images provides evidence of this recognition between an inorganic crystal surface and nanoscale structures of double-stranded DNA. This finding could open the way toward the use of the sequence-dependent adhesion to specific crystal faces for nanotechnological purposes.
Original languageEnglish
Pages (from-to)13566-13570
Number of pages5
JournalProceedings of National Academy of Sciences (PNAS) USA
Publication statusPublished - 2002


  • acidi nucleici
  • struttura


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