Recenti acquisizioni In tema d’inquinamento ambientale da farmaci

Translated title of the contribution: [Autom. eng. transl.] Recent acquisitions In terms of environmental pollution from drugs

Umberto Moscato, Gualtiero Ricciardi, Andrea Poscia, L Bellante

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

[Autom. eng. transl.] Objectives Drug pollution is a major environmental problem. In Europe, the environmental aspects of drugs have been addressed for the first time in 1993, by the 93/39 / EEC Standard. This legislation introduced the need to report any possible environmental risk potentially related to the use of medicinal products. Scientific literature indicates that drugs can be considered ubiquitous environmental pollutants, which contaminate the environment through a myriad of diffuse sources of pollution. Once administered, many drugs are not metabolized and may be excreted as such in urine or faeces. Patients, in the case of drugs for human use or animals, for veterinary drugs, are therefore considered the main source of pollution. The EMEA has recently proposed some regulatory guidelines, which are currently under discussion, to assess the environmental risk of new drugs before registration. Methods By combining the sales volumes of drugs with other factors specific to the molecules in question, the "priority" drugs are identified using the well-established methodology of "theoretical environmental loads", then the optimal analytical method is then developed for the measurement of each of them, using highly specific and sensitive techniques, such as HPLC-MS-MS, seeking confirmation of their presence and measuring concentrations in water, first in urban treatment plants, and subsequently in receiving surface waters of canals, streams, rivers and lakes. Results The evidences of the research conducted in European and US countries confirm that drug pollution is a diffuse, anthropic pollution, closely related to human presence. There are drugs used in considerable quantities that are not found in the environment because they are rapidly degraded (for example Amoxicillin), there are others, used in smaller quantities, which are found in high concentrations because they are extremely persistent (for example, Carbamazepine , Clofibric acid). Conclusions In order to protect public health, it can be concluded that possible adverse effects from chronic exposure [given the concentrations detected], with phenomena of allergies and development of antibiotic-resistances should be increasingly established. The synergistic actions already reported in the literature, on cell proliferation, of mixtures of drugs used at the concentrations actually detected in the waters of some areas of Italy, on human tissues in culture will also have to be verified.
Translated title of the contribution[Autom. eng. transl.] Recent acquisitions In terms of environmental pollution from drugs
Original languageItalian
Title of host publicationAtti del 45°Congresso Nazionale S.I.T.I
Pages359-360
Number of pages2
Publication statusPublished - 2012
Event45°Congresso Nazionale S.I.T.I - Cagliari
Duration: 3 Oct 20126 Oct 2012

Conference

Conference45°Congresso Nazionale S.I.T.I
CityCagliari
Period3/10/126/10/12

Keywords

  • farmaci
  • inquinamento ambientale

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