Rapid on-site evaluation improves the sensitivity of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for solid pancreatic lesions irrespective of technique: A single-centre experience

Sebastian Manuel Milluzzo, Nicola Olivari, Giulio Rossi, Denise Bianchi, Barbara Liserre, Massimo Graffeo, Mauro Lovera, Loredana Correale, Cesare Hassan, Cristiano Spada

Research output: Contribution to journalArticle

Abstract

Objective: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is the first-line technique for the sampling of pancreatic lesions. Many factors can influence the diagnostic performance of this procedure, including the use of rapid on-site evaluation (ROSE). The primary aim of this study was to compare the adequacy, diagnostic yield, accuracy, sensitivity and specificity of EUS-FNA for solid pancreatic lesions before and after the introduction of ROSE. Methods: This retrospective single-centre study evaluated all consecutive patients who underwent EUS-FNA for suspicious, solid pancreatic masses from April 2012 to March 2015. We compared the findings of EUS-FNA procedures performed during the first and second years following the adoption of ROSE (“ROSE1” and “ROSE2”, respectively) to those performed the year before ROSE introduction (the “pre-ROSE” group). Results: Ninety-one consecutive patients with a total of 93 pancreatic lesions were enrolled. For the pre-ROSE, ROSE1 and ROSE2 groups, the adequacy rates were 96.2%, 96.6% and 100%, the diagnostic yield values were 76.9%, 89.7% and 92.1% and accuracy values were 69.2%, 86.2% and 89.5% (p = NS). Sensitivity for malignancy improved from 63.7% in the pre-ROSE group to 91.7% and 91.2% in the post-ROSE groups (p < 0.05). Specificity for malignancy was 100% in all groups. Conclusions: ROSE can improve the diagnostic performance of EUS-FNA for solid pancreatic lesions, although only sensitivity reached statistical significance.
Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalCytopathology
Volume34
DOIs
Publication statusPublished - 2023

Keywords

  • endoscopic ultrasound
  • fine needle aspiration
  • pancreas
  • pancreatic tumour

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