RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis

Francesco Mori; Robert Nisticò; Carolina G. Nicoletti; Sara Zagaglia; Georgia Mandolesi; Sonia Piccinin; Gianvito Martino; Gaetano Martino; Annamaria Finardi; Paolo Maria Rossini; Girolama A. Marfia; Roberto Furlan; Diego Centonze

doi:10.1177/1352458515621796

RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis

Francesco Mori
, Robert Nisticò
, Carolina G. Nicoletti
, Sara Zagaglia
, Georgia Mandolesi
, Sonia Piccinin
, Gianvito Martino
, Gaetano Martino
, Annamaria Finardi
, Paolo Maria Rossini
, Girolama A. Marfia
, Roberto Furlan
, Diego Centonze

Università Cattolica del Sacro Cuore

University of Rome Tor Vergata
IRCCS Fondazione Santa Lucia - Roma
Centro Europeo di Ricerca sul Cervello, Roma
IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

26 Citations (Scopus)

Abstract

Alterations of synaptic transmission induced by inflammatory activity have been linked to the pathogenic mechanisms of multiple sclerosis (MS). Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a pro-inflammatory chemokine involved in MS pathophysiology, potentially able to regulate glutamate release and plasticity in MS brains, with relevant consequences on the clinical manifestations of the disease.

Original language	English
Pages (from-to)	N/A-N/A
Journal	Multiple sclerosis (Houndmills, Basingstoke, England)
DOIs	https://doi.org/10.1177/1352458515621796
Publication status	Published - 2016

Keywords

CSF
Chemokines
LTP
TMS
glutamate
synaptic plasticity

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10.1177/1352458515621796

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Mori, F., Nisticò, R., Nicoletti, C. G., Zagaglia, S., Mandolesi, G., Piccinin, S., Martino, G., Martino, G., Finardi, A., Rossini, P. M., Marfia, G. A., Furlan, R., & Centonze, D. (2016). RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England), N/A-N/A. https://doi.org/10.1177/1352458515621796

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title = "RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis",

abstract = "Alterations of synaptic transmission induced by inflammatory activity have been linked to the pathogenic mechanisms of multiple sclerosis (MS). Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a pro-inflammatory chemokine involved in MS pathophysiology, potentially able to regulate glutamate release and plasticity in MS brains, with relevant consequences on the clinical manifestations of the disease.",

keywords = "CSF, Chemokines, LTP, TMS, glutamate, synaptic plasticity, CSF, Chemokines, LTP, TMS, glutamate, synaptic plasticity",

author = "Francesco Mori and Robert Nistic{\`o} and Nicoletti, \{Carolina G.\} and Sara Zagaglia and Georgia Mandolesi and Sonia Piccinin and Gianvito Martino and Gaetano Martino and Annamaria Finardi and Rossini, \{Paolo Maria\} and Marfia, \{Girolama A.\} and Roberto Furlan and Diego Centonze",

year = "2016",

doi = "10.1177/1352458515621796",

language = "English",

pages = "N/A--N/A",

journal = "Multiple sclerosis (Houndmills, Basingstoke, England)",

}

Mori, F, Nisticò, R, Nicoletti, CG, Zagaglia, S, Mandolesi, G, Piccinin, S, Martino, G, Martino, G, Finardi, A, Rossini, PM, Marfia, GA, Furlan, R & Centonze, D 2016, 'RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis', Multiple sclerosis (Houndmills, Basingstoke, England), pp. N/A-N/A. https://doi.org/10.1177/1352458515621796

TY - JOUR

T1 - RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis

AU - Mori, Francesco

AU - Nisticò, Robert

AU - Nicoletti, Carolina G.

AU - Zagaglia, Sara

AU - Mandolesi, Georgia

AU - Piccinin, Sonia

AU - Martino, Gianvito

AU - Martino, Gaetano

AU - Finardi, Annamaria

AU - Rossini, Paolo Maria

AU - Marfia, Girolama A.

AU - Furlan, Roberto

AU - Centonze, Diego

PY - 2016

Y1 - 2016

N2 - Alterations of synaptic transmission induced by inflammatory activity have been linked to the pathogenic mechanisms of multiple sclerosis (MS). Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a pro-inflammatory chemokine involved in MS pathophysiology, potentially able to regulate glutamate release and plasticity in MS brains, with relevant consequences on the clinical manifestations of the disease.

AB - Alterations of synaptic transmission induced by inflammatory activity have been linked to the pathogenic mechanisms of multiple sclerosis (MS). Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a pro-inflammatory chemokine involved in MS pathophysiology, potentially able to regulate glutamate release and plasticity in MS brains, with relevant consequences on the clinical manifestations of the disease.

KW - CSF

KW - Chemokines

KW - LTP

KW - TMS

KW - glutamate

KW - synaptic plasticity

KW - CSF

KW - Chemokines

KW - LTP

KW - TMS

KW - glutamate

KW - synaptic plasticity

UR - http://hdl.handle.net/10807/94465

U2 - 10.1177/1352458515621796

DO - 10.1177/1352458515621796

M3 - Article

SP - N/A-N/A

JO - Multiple sclerosis (Houndmills, Basingstoke, England)

JF - Multiple sclerosis (Houndmills, Basingstoke, England)

ER -

RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis

Abstract

Keywords

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