Protective effects of omega‰-3 PUFA in anthracycline-induced cardiotoxicity: A critical review

Simona Serini, Gabriella Calviello, Renata Ottes Vasconcelos, Renata Nascimento Gomes

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


It has been demonstrated that omega‰-3 polyunsaturated fatty acids (omega-3 PUFA) may exert a beneficial role as adjuvants in the prevention and treatment of many disorders, including cardiovascular diseases and cancer. Particularly, several in vitro and in vivo preclinical studies have shown the antitumor activity of omega-3 PUFA in different kinds of cancers, and several human studies have shown that omega-3 PUFA are able to decrease the risk of a series of cardiovascular diseases. Several mechanisms have been proposed to explain their pleiotropic beneficial effects. omega‰-3 PUFA have also been shown to prevent harmful side-effects (including cardiotoxicity and heart failure) induced by conventional and innovative anti-cancer drugs in both animals and patients. The available literature regarding the possible protective effects of omega-3 PUFA against anthracycline-induced cardiotoxicity, as well as the mechanisms involved, will be critically discussed herein. The study will analyze the critical role of different levels of omega‰-3 PUFA intake in determining the results of the combinatory studies with anthracyclines. Suggestions for future research will also be considered.
Original languageEnglish
Pages (from-to)2689-N/A
JournalInternational Journal of Molecular Sciences
Publication statusPublished - 2017


  • Anthracyclines
  • Cardioprotection
  • Cardiotoxicity
  • Catalysis
  • Chemotherapy
  • Computer Science Applications1707 Computer Vision and Pattern Recognition
  • Inorganic Chemistry
  • Molecular Biology
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • omega‰-3 PUFA

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