Prostate cancer heterogeneity: Discovering novel molecular targets for therapy

Giampaolo Tortora, Chiara Ciccarese, Roberto Iacovelli, Francesco Massari, Michelangelo Fiorentino, Rodolfo Montironi, Vincenzo Di Nunno, Francesca Giunchi, Matteo Brunelli

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Prostate cancer (PCa) shows a broad spectrum of biological and clinical behavior, which represents the epiphenomenon of an extreme genetic heterogeneity. Recent genomic profiling studies have deeply improved the knowledge of the genomic landscape of localized and metastatic PCa. The AR and PI3K/Akt/mTOR signaling pathways are the two most frequently altered, representing therefore interestingly targets for therapy. Moreover, somatic or germline aberrations of DNA repair genes (DRGs) have been observed at high frequency, supporting the potential role of platinum derivatives and PARP inhibitors as effective therapeutic strategies. In the future, the identification of driver mutations present at a specific stage of the disease, the classification PCa based on specific molecular alterations, and the selection of the most appropriate therapy based on biomarkers predictors of response represent the foundations for an increasingly more accurate personalized medicine.
Original languageEnglish
Pages (from-to)68-73
Number of pages6
JournalCancer Treatment Reviews
Volume54
DOIs
Publication statusPublished - 2017

Keywords

  • BRCA
  • Biomarkers, Tumor
  • CRPC
  • DNA Repair
  • DRG
  • Heterogeneity
  • Humans
  • Male
  • Molecular Targeted Therapy
  • Oncology
  • PARPi
  • PTEN
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases
  • Prostate cancer
  • Prostatic Neoplasms
  • Proto-Oncogene Proteins c-akt
  • Radiology, Nuclear Medicine and Imaging
  • Receptors, Androgen
  • Signal Transduction
  • TOR Serine-Threonine Kinases

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