Prognostic value of virological and immunological responses after 6 months of antiretroviral treatment in adults with HIV-1 infection in sub-Saharan Africa

Andrea De Luca; Maria Cristina Marazzi; Sandro Mancinelli; Susanna Ceffa; Anna Maria Doro Altan; Ersilia Buonomo; Mattia Carlo Felice Prosperi; Barbara Pedruzzi; Abdul Majid Noorjehan; Paola Scarcella; Giuseppe Liotta; Leonardo Palombi

doi:10.1097/QAI.0b013e31824276e9

Prognostic value of virological and immunological responses after 6 months of antiretroviral treatment in adults with HIV-1 infection in sub-Saharan Africa

Andrea De Luca, Maria Cristina Marazzi, Sandro Mancinelli, Susanna Ceffa, Anna Maria Doro Altan, Ersilia Buonomo, Mattia Carlo Felice Prosperi, Barbara Pedruzzi, Abdul Majid Noorjehan, Paola Scarcella, Giuseppe Liotta, Leonardo Palombi

Università Cattolica del Sacro Cuore

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Abstract

HIV RNA monitoring is not available in most antiretroviral treatment (ART) programs in sub-Saharan Africa; switch to second-line therapy is mostly guided by clinical/immunological criteria. This may lead to unnecessary disease progression and drug resistance accumulation. We investigated the prognostic value of virological and immunological status 6 months after ART initiation with respect to death, loss to follow-up, and treatment switch.

Original language	English
Pages (from-to)	236-244
Number of pages	9
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	59
DOIs	https://doi.org/10.1097/QAI.0b013e31824276e9
Publication status	Published - 2012

Keywords

Adult
Africa South of the Sahara
Anti-HIV Agents
CD4 Lymphocyte Count
Cohort Studies
Drug Administration Schedule
Female
HIV Infections
HIV-1
Humans
Kaplan-Meier Estimate
Male
Patient Compliance
Predictive Value of Tests
Prospective Studies
RNA, Viral
Viral Load

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/QAI.0b013e31824276e9

Cite this

De Luca, A., Marazzi, M. C., Mancinelli, S., Ceffa, S., Altan, A. M. D., Buonomo, E., Prosperi, M. C. F., Pedruzzi, B., Noorjehan, A. M., Scarcella, P., Liotta, G., & Palombi, L. (2012). Prognostic value of virological and immunological responses after 6 months of antiretroviral treatment in adults with HIV-1 infection in sub-Saharan Africa. Journal of Acquired Immune Deficiency Syndromes, 59, 236-244. https://doi.org/10.1097/QAI.0b013e31824276e9

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title = "Prognostic value of virological and immunological responses after 6 months of antiretroviral treatment in adults with HIV-1 infection in sub-Saharan Africa",

abstract = "HIV RNA monitoring is not available in most antiretroviral treatment (ART) programs in sub-Saharan Africa; switch to second-line therapy is mostly guided by clinical/immunological criteria. This may lead to unnecessary disease progression and drug resistance accumulation. We investigated the prognostic value of virological and immunological status 6 months after ART initiation with respect to death, loss to follow-up, and treatment switch.",

keywords = "Adult, Africa South of the Sahara, Anti-HIV Agents, CD4 Lymphocyte Count, Cohort Studies, Drug Administration Schedule, Female, HIV Infections, HIV-1, Humans, Kaplan-Meier Estimate, Male, Patient Compliance, Predictive Value of Tests, Prospective Studies, RNA, Viral, Viral Load, Adult, Africa South of the Sahara, Anti-HIV Agents, CD4 Lymphocyte Count, Cohort Studies, Drug Administration Schedule, Female, HIV Infections, HIV-1, Humans, Kaplan-Meier Estimate, Male, Patient Compliance, Predictive Value of Tests, Prospective Studies, RNA, Viral, Viral Load",

author = "{De Luca}, Andrea and Marazzi, {Maria Cristina} and Sandro Mancinelli and Susanna Ceffa and Altan, {Anna Maria Doro} and Ersilia Buonomo and Prosperi, {Mattia Carlo Felice} and Barbara Pedruzzi and Noorjehan, {Abdul Majid} and Paola Scarcella and Giuseppe Liotta and Leonardo Palombi",

year = "2012",

doi = "10.1097/QAI.0b013e31824276e9",

language = "English",

volume = "59",

pages = "236--244",

journal = "Journal of Acquired Immune Deficiency Syndromes",

issn = "1525-4135",

publisher = "Wolters Kluwer Health",

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De Luca, A, Marazzi, MC, Mancinelli, S, Ceffa, S, Altan, AMD, Buonomo, E, Prosperi, MCF, Pedruzzi, B, Noorjehan, AM, Scarcella, P, Liotta, G & Palombi, L 2012, 'Prognostic value of virological and immunological responses after 6 months of antiretroviral treatment in adults with HIV-1 infection in sub-Saharan Africa', Journal of Acquired Immune Deficiency Syndromes, vol. 59, pp. 236-244. https://doi.org/10.1097/QAI.0b013e31824276e9

TY - JOUR

T1 - Prognostic value of virological and immunological responses after 6 months of antiretroviral treatment in adults with HIV-1 infection in sub-Saharan Africa

AU - De Luca, Andrea

AU - Marazzi, Maria Cristina

AU - Mancinelli, Sandro

AU - Ceffa, Susanna

AU - Altan, Anna Maria Doro

AU - Buonomo, Ersilia

AU - Prosperi, Mattia Carlo Felice

AU - Pedruzzi, Barbara

AU - Noorjehan, Abdul Majid

AU - Scarcella, Paola

AU - Liotta, Giuseppe

AU - Palombi, Leonardo

PY - 2012

Y1 - 2012

N2 - HIV RNA monitoring is not available in most antiretroviral treatment (ART) programs in sub-Saharan Africa; switch to second-line therapy is mostly guided by clinical/immunological criteria. This may lead to unnecessary disease progression and drug resistance accumulation. We investigated the prognostic value of virological and immunological status 6 months after ART initiation with respect to death, loss to follow-up, and treatment switch.

AB - HIV RNA monitoring is not available in most antiretroviral treatment (ART) programs in sub-Saharan Africa; switch to second-line therapy is mostly guided by clinical/immunological criteria. This may lead to unnecessary disease progression and drug resistance accumulation. We investigated the prognostic value of virological and immunological status 6 months after ART initiation with respect to death, loss to follow-up, and treatment switch.

KW - Adult

KW - Africa South of the Sahara

KW - Anti-HIV Agents

KW - CD4 Lymphocyte Count

KW - Cohort Studies

KW - Drug Administration Schedule

KW - Female

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Patient Compliance

KW - Predictive Value of Tests

KW - Prospective Studies

KW - RNA, Viral

KW - Viral Load

KW - Adult

KW - Africa South of the Sahara

KW - Anti-HIV Agents

KW - CD4 Lymphocyte Count

KW - Cohort Studies

KW - Drug Administration Schedule

KW - Female

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Patient Compliance

KW - Predictive Value of Tests

KW - Prospective Studies

KW - RNA, Viral

KW - Viral Load

UR - http://hdl.handle.net/10807/8325

U2 - 10.1097/QAI.0b013e31824276e9

DO - 10.1097/QAI.0b013e31824276e9

M3 - Article

SN - 1525-4135

VL - 59

SP - 236

EP - 244

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

ER -

Prognostic value of virological and immunological responses after 6 months of antiretroviral treatment in adults with HIV-1 infection in sub-Saharan Africa

Abstract

Keywords

UN SDGs

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