PROGNOSTIC RELEVANCE OF CLINICAL-PHARMACOLOGY OF ANTILEUKEMIC DRUGS

Riccardo Riccardi, Anna Lasorella, Renato Mastrangelo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Response to treatment is the most important prognostic factor in children undergoing treatment for acute lymphoblastic leukemia. Factors that interfere with the pharmacokinetic determinants of anti-leukemic compounds may cause a decreased activity of one or more of the drugs included in the treatment protocol. Noncompliance with the prescribed treatment, individual pharmacokinetic differences, interference with oral drug absorption, and different guidelines for dose reduction related to toxicity are some of the factors responsible for a decreased or variable antileukemic activity which may influence treatment results.
Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalMedical and Pediatric Oncology
Volume14
DOIs
Publication statusPublished - 1986

Keywords

  • acute leukemia
  • clinical pharmacology
  • prognosis

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