Prognostic factors in hodgkin lymphoma

Stefan Hohaus, Annarosa Cuccaro, Francesca Bartolomei, Elisa Cupelli, Manuela Giachelia

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Hodgkin lymphoma (HL) is among the neoplastic diseases that has the best long-term outcome after cytotoxic treatment. Cure rates approach 80-90%; however, 15-20% of patients will be resistant to therapy (primary refractory) or relapse after treatment. Prognostic factors should help to stratify treatment according to the risk profile and identify patients at risk for failure. Significance of prognostic factors partly depends on the efficacy of the treatments administered, since new effective therapies can variably counterbalance the adverse effects of some unfavorable clinical determinants. As a consequence, some prognostic factors thought to be important in the past may become meaningless when modern successful therapies are used. Therefore, the value of prognostic factors has to be updated periodically, and then adapted to new emerging biomarkers. Besides the prognostic role of PET imaging, tissue and circulating biomarkers, as the number of tumor-infiltrating macrophages, cytokine and chemokine levels and profiling of circulating nucleic acids (DNA and microRNAs) have shown promise.
Original languageEnglish
Pages (from-to)2014053-2014062
Number of pages10
JournalMediterranean Journal of Hematology and Infectious Diseases
Volume2014
DOIs
Publication statusPublished - 2014

Keywords

  • Hodgkin lymphoma
  • Prongostic factors

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