Preoperative radiotherapy and IORT in resectable rectal cancer at high risk for local recurrence

F Crucitti; Carlo Ratto; Luigi Sofo; G Battista Doglietto; Rocco Domenico Alfonso Bellantone; Maurizio Bossola; Liliana Sollazzi; Maria Antonietta Crea; Fm Vecchio; Alessia Piermattei

Preoperative radiotherapy and IORT in resectable rectal cancer at high risk for local recurrence

F Crucitti
, Carlo Ratto
, Luigi Sofo
, G Battista Doglietto
, Rocco Domenico Alfonso Bellantone
, Maurizio Bossola
, Liliana Sollazzi
, Maria Antonietta Crea
, Fm Vecchio
, Alessia Piermattei

Research output: Contribution to journal › Article

Abstract

Over a 4-year period 35 patients with mid- (15 patients) and low (20 patients) rectal cancer clinically staged as T2 N1-2, T3 N0-2 underwent a protocol of combined surgery and radiotherapy. The protocol included: preoperative external beam radiotherapy (38 Gy, ICRU50); surgical resection; IORT on tumor bed (10 Gy). Toxicity of preoperative treatment was mild with a single case (2.9%) of grade 3 gastrointestinal toxicity. 18 patients underwent anterior resection and 17 abdominoperineal resection. Perioperative mortality and morbidity were 0% and 17.1% respectively. At a mean follow-up of 25 months all patients were alive. The single anastomotic recurrence observed was rescued with abdominoperineal resection.

Original language	English
Pages (from-to)	190-196
Number of pages	7
Journal	RAYS
Volume	20
Publication status	Published - 1995

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Endoscopy
Follow-Up Studies
Humans
Intraoperative Care
Neoplasm Recurrence, Local
Preoperative Care
Rectal Neoplasms
Risk Factors
Time Factors

Cite this

@article{6c302760d94949d887c13b4c488135b5,

title = "Preoperative radiotherapy and IORT in resectable rectal cancer at high risk for local recurrence",

abstract = "Over a 4-year period 35 patients with mid- (15 patients) and low (20 patients) rectal cancer clinically staged as T2 N1-2, T3 N0-2 underwent a protocol of combined surgery and radiotherapy. The protocol included: preoperative external beam radiotherapy (38 Gy, ICRU50); surgical resection; IORT on tumor bed (10 Gy). Toxicity of preoperative treatment was mild with a single case (2.9\%) of grade 3 gastrointestinal toxicity. 18 patients underwent anterior resection and 17 abdominoperineal resection. Perioperative mortality and morbidity were 0\% and 17.1\% respectively. At a mean follow-up of 25 months all patients were alive. The single anastomotic recurrence observed was rescued with abdominoperineal resection.",

keywords = "Endoscopy, Follow-Up Studies, Humans, Intraoperative Care, Neoplasm Recurrence, Local, Preoperative Care, Rectal Neoplasms, Risk Factors, Time Factors, Endoscopy, Follow-Up Studies, Humans, Intraoperative Care, Neoplasm Recurrence, Local, Preoperative Care, Rectal Neoplasms, Risk Factors, Time Factors",

author = "F Crucitti and Carlo Ratto and Luigi Sofo and \{Battista Doglietto\}, G and Bellantone, \{Rocco Domenico Alfonso\} and Maurizio Bossola and Liliana Sollazzi and Crea, \{Maria Antonietta\} and Fm Vecchio and Alessia Piermattei",

year = "1995",

language = "English",

volume = "20",

pages = "190--196",

journal = "RAYS",

issn = "0390-7740",

publisher = "Ecoedizioni International srl",

}

TY - JOUR

T1 - Preoperative radiotherapy and IORT in resectable rectal cancer at high risk for local recurrence

AU - Crucitti, F

AU - Ratto, Carlo

AU - Sofo, Luigi

AU - Battista Doglietto, G

AU - Bellantone, Rocco Domenico Alfonso

AU - Bossola, Maurizio

AU - Sollazzi, Liliana

AU - Crea, Maria Antonietta

AU - Vecchio, Fm

AU - Piermattei, Alessia

PY - 1995

Y1 - 1995

N2 - Over a 4-year period 35 patients with mid- (15 patients) and low (20 patients) rectal cancer clinically staged as T2 N1-2, T3 N0-2 underwent a protocol of combined surgery and radiotherapy. The protocol included: preoperative external beam radiotherapy (38 Gy, ICRU50); surgical resection; IORT on tumor bed (10 Gy). Toxicity of preoperative treatment was mild with a single case (2.9%) of grade 3 gastrointestinal toxicity. 18 patients underwent anterior resection and 17 abdominoperineal resection. Perioperative mortality and morbidity were 0% and 17.1% respectively. At a mean follow-up of 25 months all patients were alive. The single anastomotic recurrence observed was rescued with abdominoperineal resection.

AB - Over a 4-year period 35 patients with mid- (15 patients) and low (20 patients) rectal cancer clinically staged as T2 N1-2, T3 N0-2 underwent a protocol of combined surgery and radiotherapy. The protocol included: preoperative external beam radiotherapy (38 Gy, ICRU50); surgical resection; IORT on tumor bed (10 Gy). Toxicity of preoperative treatment was mild with a single case (2.9%) of grade 3 gastrointestinal toxicity. 18 patients underwent anterior resection and 17 abdominoperineal resection. Perioperative mortality and morbidity were 0% and 17.1% respectively. At a mean follow-up of 25 months all patients were alive. The single anastomotic recurrence observed was rescued with abdominoperineal resection.

KW - Endoscopy

KW - Follow-Up Studies

KW - Humans

KW - Intraoperative Care

KW - Neoplasm Recurrence, Local

KW - Preoperative Care

KW - Rectal Neoplasms

KW - Risk Factors

KW - Time Factors

KW - Endoscopy

KW - Follow-Up Studies

KW - Humans

KW - Intraoperative Care

KW - Neoplasm Recurrence, Local

KW - Preoperative Care

KW - Rectal Neoplasms

KW - Risk Factors

KW - Time Factors

UR - http://hdl.handle.net/10807/11924

M3 - Article

SN - 0390-7740

VL - 20

SP - 190

EP - 196

JO - RAYS

JF - RAYS

ER -

Preoperative radiotherapy and IORT in resectable rectal cancer at high risk for local recurrence

Abstract

UN SDGs

Keywords

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Cite this