Preclinical evaluation of the novel 7-substituted camptothecin Namitecan (ST1968) in paediatric tumour models

Daniela Meco, Angela Maria Di Francesco, Gabriella Cusano, Federica Bucci, Filomena Pierri, Valentina Patriarca, Anna Rita Torella, Claudio Pisano, Riccardo Riccardi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The present study aimed to evaluate the new water soluble camptothecin analogue Namitecan (ST1968) in preclinical paediatric tumour models of the nervous system comprehensive of neuroblastoma, primitive neuroectodermal tumours/PNET and medulloblastoma where the drug was compared to Irinotecan.
Original languageEnglish
Pages (from-to)811-822
Number of pages12
JournalCancer Chemotherapy and Pharmacology
Volume70
DOIs
Publication statusPublished - 2012

Keywords

  • Animals
  • Antineoplastic Agents, Phytogenic
  • Antineoplastic Combined Chemotherapy Protocols
  • Apoptosis
  • Blotting, Western
  • Camptothecin
  • Cell Cycle
  • Cell Line, Tumor
  • Cerebellar Neoplasms
  • Child
  • Comet Assay
  • DNA Damage
  • Drug Synergism
  • Humans
  • Medulloblastoma
  • Mice
  • Mice, Nude
  • Neuroblastoma
  • Neuroectodermal Tumors, Primitive
  • Platinum Compounds
  • Xenograft Model Antitumor Assays

Fingerprint

Dive into the research topics of 'Preclinical evaluation of the novel 7-substituted camptothecin Namitecan (ST1968) in paediatric tumour models'. Together they form a unique fingerprint.

Cite this