Potential role for retinoic acid in patients with Cushing's disease

Francesca Pecori Giraldi; Alberto Giacinto Ambrogio; Massimiliano Andrioli; Francesca Sanguin; Iannis Karamouzis; Salvatore Maria Corsello; Carla Scaroni; Emanuela Arvat; Alfredo Pontecorvi; Francesco Cavagnini

doi:10.1210/jc.2012-2328

Potential role for retinoic acid in patients with Cushing's disease

Francesca Pecori Giraldi
, Alberto Giacinto Ambrogio
, Massimiliano Andrioli
, Francesca Sanguin
, Iannis Karamouzis
, Salvatore Maria Corsello
, Carla Scaroni
, Emanuela Arvat
, Alfredo Pontecorvi
, Francesco Cavagnini

University of Milan
University of Padua
University of Turin

Research output: Contribution to journal › Article

88 Citations (Scopus)

Abstract

Cushing's disease, i.e. cortisol excess due to an ACTH-secreting pituitary adenoma, is a rare disorder with considerable morbidity and mortality but no satisfactory medical treatment as yet. Experimental data have recently shown that retinoic acid restrains ACTH secretion by tumoral corticotropes.

Original language	English
Pages (from-to)	3577-3583
Number of pages	7
Journal	THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume	97
DOIs	https://doi.org/10.1210/jc.2012-2328
Publication status	Published - 2012

Keywords

ACTH-Secreting Pituitary Adenoma
Adenoma
Adolescent
Adrenocorticotropic Hormone
Adult
Antineoplastic Agents
Female
Humans
Hydrocortisone
Male
Middle Aged
Pituitary ACTH Hypersecretion
Prospective Studies
Treatment Outcome
Tretinoin
Young Adult

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10.1210/jc.2012-2328

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title = "Potential role for retinoic acid in patients with Cushing's disease",

abstract = "Cushing's disease, i.e. cortisol excess due to an ACTH-secreting pituitary adenoma, is a rare disorder with considerable morbidity and mortality but no satisfactory medical treatment as yet. Experimental data have recently shown that retinoic acid restrains ACTH secretion by tumoral corticotropes.",

keywords = "ACTH-Secreting Pituitary Adenoma, Adenoma, Adolescent, Adrenocorticotropic Hormone, Adult, Antineoplastic Agents, Female, Humans, Hydrocortisone, Male, Middle Aged, Pituitary ACTH Hypersecretion, Prospective Studies, Treatment Outcome, Tretinoin, Young Adult, ACTH-Secreting Pituitary Adenoma, Adenoma, Adolescent, Adrenocorticotropic Hormone, Adult, Antineoplastic Agents, Female, Humans, Hydrocortisone, Male, Middle Aged, Pituitary ACTH Hypersecretion, Prospective Studies, Treatment Outcome, Tretinoin, Young Adult",

author = "Giraldi, \{Francesca Pecori\} and Ambrogio, \{Alberto Giacinto\} and Massimiliano Andrioli and Francesca Sanguin and Iannis Karamouzis and Corsello, \{Salvatore Maria\} and Carla Scaroni and Emanuela Arvat and Alfredo Pontecorvi and Francesco Cavagnini",

year = "2012",

doi = "10.1210/jc.2012-2328",

language = "English",

volume = "97",

pages = "3577--3583",

journal = "THE JOURNAL OF CLINICAL ENDOCRINOLOGY \& METABOLISM",

issn = "1945-7197",

publisher = "Baltimore, MD : Endocrine Society",

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TY - JOUR

T1 - Potential role for retinoic acid in patients with Cushing's disease

AU - Giraldi, Francesca Pecori

AU - Ambrogio, Alberto Giacinto

AU - Andrioli, Massimiliano

AU - Sanguin, Francesca

AU - Karamouzis, Iannis

AU - Corsello, Salvatore Maria

AU - Scaroni, Carla

AU - Arvat, Emanuela

AU - Pontecorvi, Alfredo

AU - Cavagnini, Francesco

PY - 2012

Y1 - 2012

N2 - Cushing's disease, i.e. cortisol excess due to an ACTH-secreting pituitary adenoma, is a rare disorder with considerable morbidity and mortality but no satisfactory medical treatment as yet. Experimental data have recently shown that retinoic acid restrains ACTH secretion by tumoral corticotropes.

AB - Cushing's disease, i.e. cortisol excess due to an ACTH-secreting pituitary adenoma, is a rare disorder with considerable morbidity and mortality but no satisfactory medical treatment as yet. Experimental data have recently shown that retinoic acid restrains ACTH secretion by tumoral corticotropes.

KW - ACTH-Secreting Pituitary Adenoma

KW - Adenoma

KW - Adolescent

KW - Adrenocorticotropic Hormone

KW - Adult

KW - Antineoplastic Agents

KW - Female

KW - Humans

KW - Hydrocortisone

KW - Male

KW - Middle Aged

KW - Pituitary ACTH Hypersecretion

KW - Prospective Studies

KW - Treatment Outcome

KW - Tretinoin

KW - Young Adult

KW - ACTH-Secreting Pituitary Adenoma

KW - Adenoma

KW - Adolescent

KW - Adrenocorticotropic Hormone

KW - Adult

KW - Antineoplastic Agents

KW - Female

KW - Humans

KW - Hydrocortisone

KW - Male

KW - Middle Aged

KW - Pituitary ACTH Hypersecretion

KW - Prospective Studies

KW - Treatment Outcome

KW - Tretinoin

KW - Young Adult

UR - http://hdl.handle.net/10807/39263

U2 - 10.1210/jc.2012-2328

DO - 10.1210/jc.2012-2328

M3 - Article

SN - 1945-7197

VL - 97

SP - 3577

EP - 3583

JO - THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

JF - THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

ER -

Potential role for retinoic acid in patients with Cushing's disease

Abstract

Keywords

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