Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression

E Dainese; S Rodrigue; Giovanni Delogu; R Provvedi; L Laflamme; R Brzezinski; Giovanni Fadda; I Smith; L Gaudreau; G Palù; R. Manganelli

doi:10.1128/IAI.74.4.2457-2461.2006

Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression

E Dainese, S Rodrigue, Giovanni Delogu, R Provvedi, L Laflamme, R Brzezinski, Giovanni Fadda, I Smith, L Gaudreau, G Palù, R. Manganelli

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.

Original language	English
Pages (from-to)	2457-2461
Number of pages	5
Journal	Infection and Immunity
Volume	74
Issue number	4
DOIs	https://doi.org/10.1128/IAI.74.4.2457-2461.2006
Publication status	Published - 2006
Externally published	Yes

Keywords

Animals
Bacterial
Base Sequence
Gene Expression Regulation
Inbred BALB C
Inbred C57BL
Inbred DBA
Mice
Molecular Sequence Data
Mycobacterium tuberculosis
Post-Translational
Protein Processing
Pulmonary
Sigma Factor
Tuberculosis
Virulence Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/IAI.74.4.2457-2461.2006

Cite this

Dainese, E., Rodrigue, S., Delogu, G., Provvedi, R., Laflamme, L., Brzezinski, R., Fadda, G., Smith, I., Gaudreau, L., Palù, G., & Manganelli, R. (2006). Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression. Infection and Immunity, 74(4), 2457-2461. https://doi.org/10.1128/IAI.74.4.2457-2461.2006

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title = "Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression",

abstract = "In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.",

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author = "E Dainese and S Rodrigue and Giovanni Delogu and R Provvedi and L Laflamme and R Brzezinski and Giovanni Fadda and I Smith and L Gaudreau and G Pal{\`u} and R. Manganelli",

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doi = "10.1128/IAI.74.4.2457-2461.2006",

language = "English",

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pages = "2457--2461",

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Dainese, E, Rodrigue, S, Delogu, G, Provvedi, R, Laflamme, L, Brzezinski, R, Fadda, G, Smith, I, Gaudreau, L, Palù, G & Manganelli, R 2006, 'Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression', Infection and Immunity, vol. 74, no. 4, pp. 2457-2461. https://doi.org/10.1128/IAI.74.4.2457-2461.2006

TY - JOUR

T1 - Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression

AU - Dainese, E

AU - Rodrigue, S

AU - Delogu, Giovanni

AU - Provvedi, R

AU - Laflamme, L

AU - Brzezinski, R

AU - Fadda, Giovanni

AU - Smith, I

AU - Gaudreau, L

AU - Palù, G

AU - Manganelli, R.

PY - 2006

Y1 - 2006

N2 - In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.

AB - In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.

KW - Animals

KW - Bacterial

KW - Base Sequence

KW - Gene Expression Regulation

KW - Inbred BALB C

KW - Inbred C57BL

KW - Inbred DBA

KW - Mice

KW - Molecular Sequence Data

KW - Mycobacterium tuberculosis

KW - Post-Translational

KW - Protein Processing

KW - Pulmonary

KW - Sigma Factor

KW - Tuberculosis

KW - Virulence Factors

KW - Animals

KW - Bacterial

KW - Base Sequence

KW - Gene Expression Regulation

KW - Inbred BALB C

KW - Inbred C57BL

KW - Inbred DBA

KW - Mice

KW - Molecular Sequence Data

KW - Mycobacterium tuberculosis

KW - Post-Translational

KW - Protein Processing

KW - Pulmonary

KW - Sigma Factor

KW - Tuberculosis

KW - Virulence Factors

UR - https://publicatt.unicatt.it/handle/10807/6594

U2 - 10.1128/IAI.74.4.2457-2461.2006

DO - 10.1128/IAI.74.4.2457-2461.2006

M3 - Article

SN - 0019-9567

VL - 74

SP - 2457

EP - 2461

JO - Infection and Immunity

JF - Infection and Immunity

IS - 4

ER -

Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression

Abstract

Keywords

UN SDGs

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