TY - JOUR
T1 - Post-mortem stability and redistribution of carbohydrate-deficient transferrin (CDT)
AU - De Giorgio, Fabio
AU - Rainio, Juha Kaleva
AU - Tagliaro, Franco
AU - De Paoli, G
AU - Druid, H
AU - Kauppila, R
AU - Bortolotti, Federica
PY - 2008
Y1 - 2008
N2 - Post-mortem diagnosis of chronic alcohol abuse is a challenge for forensic experts due to the lack of pathognomonic morphological findings and often also inadequate background information. Objective methods demonstrating chronic excessive alcohol consumption would therefore be a useful tool for forensic pathologists. In clinical practice, several markers of chronic alcohol abuse have recently been introduced, among which carbohydrate-deficient transferrin (CDT) is the most accepted, but the use of these markers in autopsy has not yet been established. We examined post-mortem stability and possible post-mortem redistribution of CDT and compared two analytical methods, capillary zone electrophoresis and high-performance liquid chromatography. According to our results, CDT remains stable for an appreciable time after death. The results further indicate that CDT is not subject to major post-mortem redistribution.
AB - Post-mortem diagnosis of chronic alcohol abuse is a challenge for forensic experts due to the lack of pathognomonic morphological findings and often also inadequate background information. Objective methods demonstrating chronic excessive alcohol consumption would therefore be a useful tool for forensic pathologists. In clinical practice, several markers of chronic alcohol abuse have recently been introduced, among which carbohydrate-deficient transferrin (CDT) is the most accepted, but the use of these markers in autopsy has not yet been established. We examined post-mortem stability and possible post-mortem redistribution of CDT and compared two analytical methods, capillary zone electrophoresis and high-performance liquid chromatography. According to our results, CDT remains stable for an appreciable time after death. The results further indicate that CDT is not subject to major post-mortem redistribution.
KW - carbohydrate-deficient transferrin
KW - carbohydrate-deficient transferrin
UR - http://hdl.handle.net/10807/12576
M3 - Article
SP - 161
EP - 165
JO - Forensic Science International
JF - Forensic Science International
SN - 0379-0738
ER -