PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity

A. Mosca; Casale A. Del; M. Borro; G. Gentile; L. M. Pomes; A. Padovano; F. Fiasche; V. Pinzone; C. Rapinesi; T. Zoppi; R. Brugnoli; Gabriele Sani; G. D. Kotzalidis; P. Girardi; S. Ferracuti; M. Simmaco; Maurizio Pompili

doi:10.2217/pme-2019-0141

PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity

A. Mosca
, Casale A. Del^*
, M. Borro
, G. Gentile
, L. M. Pomes
, A. Padovano
, F. Fiasche
, V. Pinzone
, C. Rapinesi
, T. Zoppi
, R. Brugnoli
, Gabriele Sani
, G. D. Kotzalidis
, P. Girardi
, S. Ferracuti
, M. Simmaco
, Maurizio Pompili

^*Corresponding author

Research output: Contribution to journal › Article

Abstract

Background: Multiple chemical sensitivity (MCS) is a chronic condition with somatic, cognitive and affective symptoms that follow contact with chemical agents at usually non toxic concentrations. We aimed to assess the role of genetic polymorphisms involved in oxidative stress on anxiety and depression in MCS. Materials & methods: Our study investigated the CAT rs1001179, MPO rs2333227, PON1 rs662 and PON1 rs705379 polymorphisms in MCS. Results: The AG genotype of the PON1 rs662 and the TT and CT genotypes of the PON1 rs705379 were involved in anxiety and depression. Discussion: These results are in line with existing evidence of PON1 involvement in MCS and suggest a further role of this gene in the exhibition of anxiety and depression in this disease.

Original language	English
Pages (from-to)	255-267
Number of pages	13
Journal	Personalized Medicine
Volume	18
Issue number	3
DOIs	https://doi.org/10.2217/pme-2019-0141
Publication status	Published - 2021

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology

Keywords

anxiety
depression
genomics
hyperosmia
multiple chemical sensitivity
oxidative stress
paraoxonase

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Mosca, A., Del, C. A., Borro, M., Gentile, G., Pomes, L. M., Padovano, A., Fiasche, F., Pinzone, V., Rapinesi, C., Zoppi, T., Brugnoli, R., Sani, G., Kotzalidis, G. D., Girardi, P., Ferracuti, S., Simmaco, M., & Pompili, M. (2021). PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity. Personalized Medicine, 18(3), 255-267. https://doi.org/10.2217/pme-2019-0141

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title = "PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity",

abstract = "Background: Multiple chemical sensitivity (MCS) is a chronic condition with somatic, cognitive and affective symptoms that follow contact with chemical agents at usually non toxic concentrations. We aimed to assess the role of genetic polymorphisms involved in oxidative stress on anxiety and depression in MCS. Materials \& methods: Our study investigated the CAT rs1001179, MPO rs2333227, PON1 rs662 and PON1 rs705379 polymorphisms in MCS. Results: The AG genotype of the PON1 rs662 and the TT and CT genotypes of the PON1 rs705379 were involved in anxiety and depression. Discussion: These results are in line with existing evidence of PON1 involvement in MCS and suggest a further role of this gene in the exhibition of anxiety and depression in this disease.",

keywords = "anxiety, depression, genomics, hyperosmia, multiple chemical sensitivity, oxidative stress, paraoxonase, anxiety, depression, genomics, hyperosmia, multiple chemical sensitivity, oxidative stress, paraoxonase",

author = "A. Mosca and Del, \{Casale A.\} and M. Borro and G. Gentile and Pomes, \{L. M.\} and A. Padovano and F. Fiasche and V. Pinzone and C. Rapinesi and T. Zoppi and R. Brugnoli and Gabriele Sani and Kotzalidis, \{G. D.\} and P. Girardi and S. Ferracuti and M. Simmaco and Maurizio Pompili",

year = "2021",

doi = "10.2217/pme-2019-0141",

language = "English",

volume = "18",

pages = "255--267",

journal = "Personalized Medicine",

issn = "1741-0541",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

Mosca, A, Del, CA, Borro, M, Gentile, G, Pomes, LM, Padovano, A, Fiasche, F, Pinzone, V, Rapinesi, C, Zoppi, T, Brugnoli, R, Sani, G, Kotzalidis, GD, Girardi, P, Ferracuti, S, Simmaco, M & Pompili, M 2021, 'PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity', Personalized Medicine, vol. 18, no. 3, pp. 255-267. https://doi.org/10.2217/pme-2019-0141

TY - JOUR

T1 - PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity

AU - Mosca, A.

AU - Del, Casale A.

AU - Borro, M.

AU - Gentile, G.

AU - Pomes, L. M.

AU - Padovano, A.

AU - Fiasche, F.

AU - Pinzone, V.

AU - Rapinesi, C.

AU - Zoppi, T.

AU - Brugnoli, R.

AU - Sani, Gabriele

AU - Kotzalidis, G. D.

AU - Girardi, P.

AU - Ferracuti, S.

AU - Simmaco, M.

AU - Pompili, Maurizio

PY - 2021

Y1 - 2021

N2 - Background: Multiple chemical sensitivity (MCS) is a chronic condition with somatic, cognitive and affective symptoms that follow contact with chemical agents at usually non toxic concentrations. We aimed to assess the role of genetic polymorphisms involved in oxidative stress on anxiety and depression in MCS. Materials & methods: Our study investigated the CAT rs1001179, MPO rs2333227, PON1 rs662 and PON1 rs705379 polymorphisms in MCS. Results: The AG genotype of the PON1 rs662 and the TT and CT genotypes of the PON1 rs705379 were involved in anxiety and depression. Discussion: These results are in line with existing evidence of PON1 involvement in MCS and suggest a further role of this gene in the exhibition of anxiety and depression in this disease.

AB - Background: Multiple chemical sensitivity (MCS) is a chronic condition with somatic, cognitive and affective symptoms that follow contact with chemical agents at usually non toxic concentrations. We aimed to assess the role of genetic polymorphisms involved in oxidative stress on anxiety and depression in MCS. Materials & methods: Our study investigated the CAT rs1001179, MPO rs2333227, PON1 rs662 and PON1 rs705379 polymorphisms in MCS. Results: The AG genotype of the PON1 rs662 and the TT and CT genotypes of the PON1 rs705379 were involved in anxiety and depression. Discussion: These results are in line with existing evidence of PON1 involvement in MCS and suggest a further role of this gene in the exhibition of anxiety and depression in this disease.

KW - anxiety

KW - depression

KW - genomics

KW - hyperosmia

KW - multiple chemical sensitivity

KW - oxidative stress

KW - paraoxonase

KW - anxiety

KW - depression

KW - genomics

KW - hyperosmia

KW - multiple chemical sensitivity

KW - oxidative stress

KW - paraoxonase

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U2 - 10.2217/pme-2019-0141

DO - 10.2217/pme-2019-0141

M3 - Article

SN - 1741-0541

VL - 18

SP - 255

EP - 267

JO - Personalized Medicine

JF - Personalized Medicine

IS - 3

ER -

PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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