PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity

Alessio Mosca; Antonio Del Casale; Marina Borro; Giovanna Gentile; Giuseppe Gentile; Leda Marina Pomes; Alessio Padovano; Federica Fiaschè; Vito Pinzone; Chiara Rapinesi; Teodolinda Zoppi; Roberto Brugnoli; Gabriele Sani; Georgios Demetrios Kotzalidis; Paolo Girardi; Stefano Ferracuti; Maurizio Simmaco; Maurizio Pompili

doi:10.2217/pme-2019-0141

PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity

Alessio Mosca, Antonio Del Casale, Marina Borro, Giovanna Gentile, Giuseppe Gentile, Leda Marina Pomes, Alessio Padovano, Federica Fiaschè, Vito Pinzone, Chiara Rapinesi, Teodolinda Zoppi, Roberto Brugnoli, Gabriele Sani, Georgios Demetrios Kotzalidis, Paolo Girardi, Stefano Ferracuti, Maurizio Simmaco, Maurizio Pompili

Research output: Contribution to journal › Article

Abstract

Background: Multiple chemical sensitivity (MCS) is a chronic condition with somatic, cognitive and affective symptoms that follow contact with chemical agents at usually non toxic concentrations. We aimed to assess the role of genetic polymorphisms involved in oxidative stress on anxiety and depression in MCS. Materials & methods: Our study investigated the CAT rs1001179, MPO rs2333227, PON1 rs662 and PON1 rs705379 polymorphisms in MCS. Results: The AG genotype of the PON1 rs662 and the TT and CT genotypes of the PON1 rs705379 were involved in anxiety and depression. Discussion: These results are in line with existing evidence of PON1 involvement in MCS and suggest a further role of this gene in the exhibition of anxiety and depression in this disease.

Original language	English
Pages (from-to)	255-267
Number of pages	13
Journal	Personalized Medicine
Volume	18
DOIs	https://doi.org/10.2217/pme-2019-0141
Publication status	Published - 2021

Keywords

anxiety
depression
genomics
hyperosmia
multiple chemical sensitivity
oxidative stress
paraoxonase

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10.2217/pme-2019-0141

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Mosca, A., Del Casale, A., Borro, M., Gentile, G., Gentile, G., Pomes, L. M., Padovano, A., Fiaschè, F., Pinzone, V., Rapinesi, C., Zoppi, T., Brugnoli, R., Sani, G., Kotzalidis, G. D., Girardi, P., Ferracuti, S., Simmaco, M., & Pompili, M. (2021). PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity. Personalized Medicine, 18, 255-267. https://doi.org/10.2217/pme-2019-0141

@article{5ad5cf8c37194828a71f9a7505a39bf4,

title = "PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity",

abstract = "Background: Multiple chemical sensitivity (MCS) is a chronic condition with somatic, cognitive and affective symptoms that follow contact with chemical agents at usually non toxic concentrations. We aimed to assess the role of genetic polymorphisms involved in oxidative stress on anxiety and depression in MCS. Materials & methods: Our study investigated the CAT rs1001179, MPO rs2333227, PON1 rs662 and PON1 rs705379 polymorphisms in MCS. Results: The AG genotype of the PON1 rs662 and the TT and CT genotypes of the PON1 rs705379 were involved in anxiety and depression. Discussion: These results are in line with existing evidence of PON1 involvement in MCS and suggest a further role of this gene in the exhibition of anxiety and depression in this disease.",

keywords = "anxiety, depression, genomics, hyperosmia, multiple chemical sensitivity, oxidative stress, paraoxonase, anxiety, depression, genomics, hyperosmia, multiple chemical sensitivity, oxidative stress, paraoxonase",

author = "Alessio Mosca and {Del Casale}, Antonio and Marina Borro and Giovanna Gentile and Giuseppe Gentile and Pomes, {Leda Marina} and Alessio Padovano and Federica Fiasch{\`e} and Vito Pinzone and Chiara Rapinesi and Teodolinda Zoppi and Roberto Brugnoli and Gabriele Sani and Kotzalidis, {Georgios Demetrios} and Paolo Girardi and Stefano Ferracuti and Maurizio Simmaco and Maurizio Pompili",

year = "2021",

doi = "10.2217/pme-2019-0141",

language = "English",

volume = "18",

pages = "255--267",

journal = "Personalized Medicine",

issn = "1741-0541",

publisher = "Taylor and Francis Ltd.",

}

Mosca, A, Del Casale, A, Borro, M, Gentile, G, Gentile, G, Pomes, LM, Padovano, A, Fiaschè, F, Pinzone, V, Rapinesi, C, Zoppi, T, Brugnoli, R, Sani, G, Kotzalidis, GD, Girardi, P, Ferracuti, S, Simmaco, M & Pompili, M 2021, 'PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity', Personalized Medicine, vol. 18, pp. 255-267. https://doi.org/10.2217/pme-2019-0141

TY - JOUR

T1 - PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity

AU - Mosca, Alessio

AU - Del Casale, Antonio

AU - Borro, Marina

AU - Gentile, Giovanna

AU - Gentile, Giuseppe

AU - Pomes, Leda Marina

AU - Padovano, Alessio

AU - Fiaschè, Federica

AU - Pinzone, Vito

AU - Rapinesi, Chiara

AU - Zoppi, Teodolinda

AU - Brugnoli, Roberto

AU - Sani, Gabriele

AU - Kotzalidis, Georgios Demetrios

AU - Girardi, Paolo

AU - Ferracuti, Stefano

AU - Simmaco, Maurizio

AU - Pompili, Maurizio

PY - 2021

Y1 - 2021

N2 - Background: Multiple chemical sensitivity (MCS) is a chronic condition with somatic, cognitive and affective symptoms that follow contact with chemical agents at usually non toxic concentrations. We aimed to assess the role of genetic polymorphisms involved in oxidative stress on anxiety and depression in MCS. Materials & methods: Our study investigated the CAT rs1001179, MPO rs2333227, PON1 rs662 and PON1 rs705379 polymorphisms in MCS. Results: The AG genotype of the PON1 rs662 and the TT and CT genotypes of the PON1 rs705379 were involved in anxiety and depression. Discussion: These results are in line with existing evidence of PON1 involvement in MCS and suggest a further role of this gene in the exhibition of anxiety and depression in this disease.

AB - Background: Multiple chemical sensitivity (MCS) is a chronic condition with somatic, cognitive and affective symptoms that follow contact with chemical agents at usually non toxic concentrations. We aimed to assess the role of genetic polymorphisms involved in oxidative stress on anxiety and depression in MCS. Materials & methods: Our study investigated the CAT rs1001179, MPO rs2333227, PON1 rs662 and PON1 rs705379 polymorphisms in MCS. Results: The AG genotype of the PON1 rs662 and the TT and CT genotypes of the PON1 rs705379 were involved in anxiety and depression. Discussion: These results are in line with existing evidence of PON1 involvement in MCS and suggest a further role of this gene in the exhibition of anxiety and depression in this disease.

KW - anxiety

KW - depression

KW - genomics

KW - hyperosmia

KW - multiple chemical sensitivity

KW - oxidative stress

KW - paraoxonase

KW - anxiety

KW - depression

KW - genomics

KW - hyperosmia

KW - multiple chemical sensitivity

KW - oxidative stress

KW - paraoxonase

UR - http://hdl.handle.net/10807/201352

U2 - 10.2217/pme-2019-0141

DO - 10.2217/pme-2019-0141

M3 - Article

SN - 1741-0541

VL - 18

SP - 255

EP - 267

JO - Personalized Medicine

JF - Personalized Medicine

ER -

PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity

Abstract

Keywords

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