Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes

Emiliano Fabiani; Francesco D'Alo'; Alessandra Scardocci; Mariangela Greco; Annalisa Di Ruscio; Marianna Criscuolo; Luana Fianchi; Livio Pagano; Stefan Hohaus; Giuseppe Leone; Maria Teresa Voso

doi:10.1016/j.leukres.2008.10.012

Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes

Emiliano Fabiani
, Francesco D'Alo'
, Alessandra Scardocci
, Mariangela Greco
, Annalisa Di Ruscio
, Marianna Criscuolo
, Luana Fianchi
, Livio Pagano
, Stefan Hohaus
, Giuseppe Leone
, Maria Teresa Voso

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p=0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p=0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis.

Original language	English
Pages (from-to)	1068-1071
Number of pages	4
Journal	Leukemia Research
Volume	2009
DOIs	https://doi.org/10.1016/j.leukres.2008.10.012
Publication status	Published - 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DNA repair
Detoxiifcation enzymes
Myelodysplastic syndromes
Polymorphism

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10.1016/j.leukres.2008.10.012

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@article{dcc37dbaa07442309fc3ad3806c96166,

title = "Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes",

abstract = "The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p=0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p=0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis.",

keywords = "DNA repair, Detoxiifcation enzymes, Myelodysplastic syndromes, Polymorphism, DNA repair, Detoxiifcation enzymes, Myelodysplastic syndromes, Polymorphism",

author = "Emiliano Fabiani and Francesco D'Alo' and Alessandra Scardocci and Mariangela Greco and \{Di Ruscio\}, Annalisa and Marianna Criscuolo and Luana Fianchi and Livio Pagano and Stefan Hohaus and Giuseppe Leone and Voso, \{Maria Teresa\}",

year = "2009",

doi = "10.1016/j.leukres.2008.10.012",

language = "English",

volume = "2009",

pages = "1068--1071",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes

AU - Fabiani, Emiliano

AU - D'Alo', Francesco

AU - Scardocci, Alessandra

AU - Greco, Mariangela

AU - Di Ruscio, Annalisa

AU - Criscuolo, Marianna

AU - Fianchi, Luana

AU - Pagano, Livio

AU - Hohaus, Stefan

AU - Leone, Giuseppe

AU - Voso, Maria Teresa

PY - 2009

Y1 - 2009

N2 - The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p=0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p=0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis.

AB - The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p=0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p=0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis.

KW - DNA repair

KW - Detoxiifcation enzymes

KW - Myelodysplastic syndromes

KW - Polymorphism

KW - DNA repair

KW - Detoxiifcation enzymes

KW - Myelodysplastic syndromes

KW - Polymorphism

UR - http://hdl.handle.net/10807/6327

U2 - 10.1016/j.leukres.2008.10.012

DO - 10.1016/j.leukres.2008.10.012

M3 - Article

SN - 0145-2126

VL - 2009

SP - 1068

EP - 1071

JO - Leukemia Research

JF - Leukemia Research

ER -

Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes

Abstract

UN SDGs

Keywords

Access to Document

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