Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes

Francesco D'Alo', Livio Pagano, Stefan Hohaus, Emiliano Fabiani, Alessandra Scardocci, Mariangela Greco, Annalisa Di Ruscio, Marianna Criscuolo, Luana Fianchi, Giuseppe Leone, Maria Teresa Voso

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p=0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p=0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis.
Original languageEnglish
Pages (from-to)1068-1071
Number of pages4
JournalLeukemia Research
Volume2009
Publication statusPublished - 2009

Keywords

  • DNA repair
  • Detoxiifcation enzymes
  • Myelodysplastic syndromes
  • Polymorphism

Fingerprint

Dive into the research topics of 'Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes'. Together they form a unique fingerprint.

Cite this