Abstract
There is no agreement on which channel is involved in oxaliplatin neurotoxicity, most investigators favouring voltage-gated sodium channels. However, the small conductance Ca(++) activated K(+) channels, encoded by the SK1-3 genes, are also involved in membrane excitability, playing a role in after-hyperpolarization at the motor nerve terminal. As the SK3 gene is characterized in Caucasians by a highly polymorphic CAG motif within the exon 1, we hypothesize that SK3 gene polymorphism may influence the development of acute nerve hyperexcitability in oxaliplatin-treated patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1179-1187 |
| Number of pages | 9 |
| Journal | Cancer Chemotherapy and Pharmacology |
| Volume | 67 |
| DOIs | |
| Publication status | Published - 2011 |
Keywords
- Aged
- Amino Acid Motifs
- Antineoplastic Agents
- Biliary Tract Neoplasms
- Colorectal Neoplasms
- Electromyography
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Male
- Neoplasms
- Neural Conduction
- Neurologic Examination
- Organoplatinum Compounds
- Pancreatic Neoplasms
- Peripheral Nervous System Diseases
- Polymorphism, Genetic
- Small-Conductance Calcium-Activated Potassium Channels
- Stomach Neoplasms
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