Polymorphism in cytokine genes as prognostic markers in Hodgkin's lymphoma

Stefan Hohaus, Maurizio Martini, Francesco D'Alo', Francesco Pierconti, Luigi Maria Larocca, Annalaura Di Febo, Giuseppina Massini, Francesco Guidi, Maria Teresa Voso, Manuela Giachelia, Barbara Vannata, Maria Angela Greco, Giuseppe Leone

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

In Hodgkin's lymphoma (HL), the production of cytokines by Reed-Sternberg cells and the surrounding tissue is thought to contribute to the biology of the disease. Cytokine expression can be altered by common single nucleotide polymorphisms (SNPs) in the 5'-promoter regions.
Original languageEnglish
Pages (from-to)1376-1381
Number of pages6
JournalAnnals of Oncology
Volume18
DOIs
Publication statusPublished - 2007

Keywords

  • Adolescent
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols
  • Female
  • Hodgkin Disease
  • Humans
  • Interleukin-10
  • Interleukin-6
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Single Nucleotide
  • Prognosis
  • Promoter Regions, Genetic
  • Tumor Markers, Biological
  • Tumor Necrosis Factor-alpha

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