Polyglandular autoimmune diseases in a dermatological clinical setting: vitiligo-associated autoimmune diseases

Paolo Amerio, D Di Rollo, A Carbone, M Auriemma, Me Marra, P De Remigis, Claudio Feliciani, M Tracanna, A. Tulli

Research output: Contribution to journalArticle


Vitiligo is an acquired hypomelanotic disorder characterized by depigmented macules resulting from the loss of functional melanocytes. Many different etiological hypotheses have been suggested for vitiligo, the most recent of which involves a combination of interacting environmental and genetic factors. Among the various pieces of evidence in support of an autoimmune origin of vitiligo, there is the epidemiological association with several autoimmune diseases. The most frequently reported association is with autoimmune thyroiditis; however, other diseases such as rheumatoid arthritis, diabetes mellitus, pernicious anemia and chronic urticaria have been described in variable percentages, depending upon the genetics of the population studied. Among the diseases described in association with vitiligo there are the so-called autoimmune polyglandular syndromes (APS). Here we report 31 cases of APS diagnosed in 113 vitiligo patients, according to the newest classification. Autoimmune association was more present in generalized non segmental vitiligo and was more frequent in females. The most frequent association was with thyroid autoimmune disease, followed by autoimmune gastritis and alopecia areata. ANA positivity was similar to that reported previously in the general population. We stress the importance of an assessment for autoimmune diseases in vitiligo patients.
Original languageEnglish
Pages (from-to)354-358
Number of pages5
JournalEuropean Journal of Dermatology
Publication statusPublished - 2010
Externally publishedYes


  • Adult
  • Aged
  • Autoantibodies
  • Autoimmunity
  • Female
  • Humans
  • Incidence
  • Italy
  • Male
  • Middle Aged
  • Polyendocrinopathies, Autoimmune
  • Prevalence
  • Retrospective Studies
  • Vitiligo
  • Young Adult


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