BACKGROUND AND OBJECTIVES:
Pneumonectomy for non small cell lung cancer
(NSCLC) after induction radio-chemotherapy
(IT) has been associated with high peri-operative
risk and its safety and efficacy is still debated.
The aim of this retrospective study was
to compare short and long-term results of
pneumonectomy in patients treated with and
without IT (radiotherapy plus chemotherapy) for
MATERIALS AND METHODS: From 1995 to
2008, 85 consecutive patients underwent pneumonectomy:
49 received pre-operative radiotherapy
and chemotherapy (IT group), and 36 patients
did not (non-IT group). Peri-operative and
long-term outcomes were compared.
RESULTS: Major complications rate was 14.3%
for IT group and 16.7% for non-IT group (p = n.s.).
Mortality rate was 2% in IT group and 5.5% in non-
IT group (p = n.s.). Post-operative hospital stay
was significantly longer in the IT group (p <
0.0001) as the need for blood transfusion (p =
0.002). Indeed, the mortality rate was similar in the
left- and right-sided operations. 5 years survival
was 45.3% for IT group and 38.4% for non-IT
group (p = n.s.) and 5 year disease free survival
rates were 42.3% vs. 37.8% for the two groups, respectively
(p = n.s.). Among the clinical, surgical
and pathological features no differences on long
term outcomes were found with regards to IT.
DISCUSSION: Pneumonectomy is a feasible
and safe procedure even after pre-operative IT.
Our results showed a prolonged hospitalization
and the need for blood transfusion in the IT
- Non small cell lung cancer