Platelet indices and glucose control in type 1 and type 2 diabetes mellitus: A case-control study

Bianca Rocca, Luciana Teofili, Valerio De Stefano, Dario Pitocco, Francesco Zaccardi, Alessandro Rizzi, Angela Maria Ciminello, Giovanni Ghirlanda

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background and aims: The relationship between platelet indices and glucose control may differ in type 1 (T1DM) and type 2 (T2DM) diabetes. We aimed to investigate differences in mean platelet volume (MPV), platelet count, and platelet mass between patients with T1DM, T2DM, and healthy controls and to explore associations between these platelet indices and glucose control. Methods and results: A total of 691 T1DM and 459 T2DM patients and 943 control subjects (blood donors) were included. HbA1c was measured in all subjects with diabetes and 36 T1DM patients further underwent 24 h-continuous glucose monitoring to estimate short-term glucose control (glucose mean and standard deviation). Adjusting for age and sex, platelet count was higher and MPV lower in both T1DM and T2DM patients vs control subjects, while platelet mass (MPV × platelet count) resulted higher only in T2DM. Upon further adjustment for HbA1c, differences in platelet count and mass were respectively 19.5 × 109/L (95%CI: 9.8-29.3; p < 0.001) and 101 fL/nL (12-191; p = 0.027) comparing T2DM vs T1DM patients. MPV and platelet count were significantly and differently related in T2DM patients vs both T1DM and control subjects; this difference was maintained also accounting for HbA1c, age, and sex. Platelet mass and the volume-count relationship were significantly related to HbA1c only in T1DM patients. No associations were found between platelet indices and short-term glucose control. Conclusion: By accounting for confounders and glucose control, our data evidenced higher platelet mass and different volume-count kinetics in subjects with T2DM vs T1DM. Long-term glucose control seemed to influence platelet mass and the volume-count relationship only in T1DM subjects. These findings suggest different mechanisms behind platelet formation in T1DM and T2DM patients with long-term glycaemic control being more relevant in T1DM than T2DM.
Original languageEnglish
Pages (from-to)902-909
Number of pages8
JournalNMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Volume27
DOIs
Publication statusPublished - 2017

Keywords

  • Adult
  • Biomarkers
  • Blood Glucose
  • Blood Platelets
  • Cardiology and Cardiovascular Medicine
  • Case-control
  • Diabetes Mellitus, Type 1
  • Diabetes Mellitus, Type 2
  • Endocrinology, Diabetes and Metabolism
  • Female
  • Glycated Hemoglobin A
  • Humans
  • Hypoglycemic Agents
  • Kinetics
  • Male
  • Mean Platelet Volume
  • Medicine (miscellaneous)
  • Middle Aged
  • Nutrition and Dietetics
  • Platelet Count
  • Platelet count
  • Platelet turnover
  • Platelet volume
  • Retrospective Studies
  • Type 1 diabetes
  • Type 2 diabetes

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