Platelet hyaluronidase 2 enrichment in acute coronary syndromes: a conceivable role in monocyte-platelet aggregate formation

Ramona Vinci, Massimo Massetti, Filippo Crea, Giovanna Liuzzo, Daniela Pedicino, Pellegrino Ciampi, Myriana Ponzo, Alice Bonanni, Rocco Antonio Montone

Research output: Contribution to journalArticle

Abstract

Acute Coronary Syndromes (ACS) with plaque erosion display dysregulated hyaluronan metabolism, with increased hyaluronidase-2 (HYAL2) expression. However, the expression and the role of this enzyme on platelets has never been explored. We evaluated the platelet’s HYAL2 (pltHYAL2) levels on I) stable angina (SA) and II) ACS patients, furtherly sub-grouped in Intact-Fibrous-Cap (IFC) and Ruptured-Fibrous-Cap (RFC), according to Optical Coherence Tomography. We assessed the HYAL2 role through an in vitro model setting of co-cultured monocytes and platelets, before and after treatment with low-molecular-weight hyaluronic acid (HA) as pro-inflammatory stimulus and with or without HYAL2-antibody to inhibit HYAL2 activity. ACS patients exhibit higher pltHYAL2 levels comparing to SA, with the higher expression for IFC group. The addition of HYAL2-antibody significantly reduced the percentage of monocyte-platelet binding, suggesting that pltHYAL2 enrichment at the site of the culprit lesion is a key mediator in the systemic thrombo-inflammatory status of ACS presenting with plaque erosion.
Original languageEnglish
Pages (from-to)785-789
Number of pages5
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume36
DOIs
Publication statusPublished - 2021

Keywords

  • Acute coronary syndromes
  • hyaluronic acid
  • hyaluronidase
  • personalised medicine
  • platelets

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