Pituitary adenomas and invasiveness from anatomo-surgical, radiological, and histological perspectives: A systematic literature review

Simona Serioli, Francesco Doglietto, Alessandro Fiorindi, Antonio Biroli, Davide Mattavelli, Barbara Buffoli, Marco Ferrari, Claudio Cornali, Luigi Rodella, Roberto Maroldi, Roberto Gasparotti, Piero Nicolai, Marco Maria Fontanella, Pietro Luigi Poliani

Research output: Contribution to journalArticlepeer-review

Abstract

Invasiveness in pituitary adenomas has been defined and investigated from multiple perspectives, with varying results when its predictive value is considered. A systematic literature review, following PRISMA guidelines, was performed, searching PubMed and Scopus databases with terms that included molecular markers, histological, radiological, anatomical and surgical data on invasiveness of pituitary adenomas. The results showed that differing views are still present for anatomical aspects of the sellar region that are relevant to the concept of invasiveness; radiological and histological diagnoses are still limited, but might improve in the future, especially if they are related to surgical findings, which have become more accurate thanks to the introduction of the endoscope. The aim is to achieve a correct distinction between truly invasive pituitary adenomas from those that, in contrast, present with extension in the parasellar area through natural pathways. At present, diagnosis of invasiveness should be based on a comprehensive analysis of radiological, intraoperative and histological findings.
Original languageEnglish
Pages (from-to)1936-1957
Number of pages21
JournalCancers
Volume11
DOIs
Publication statusPublished - 2019

Keywords

  • Anatomy
  • Cavernous sinus
  • Classification
  • Diagnosis
  • Histology
  • Invasiveness
  • PitNET
  • Pituitary adenoma
  • Radiology
  • Surgery

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