Abstract
Preliminary results of a pilot study on congenital hypothyroidism performed on 8,025 newborns in Italy over a 10-month period are reported. The determination of both T4 and TSH on dried blood, spotted on filter paper, as screening procedure at day 3-5 of life revealed three cases of primary hypothyroidism and one case of hypo-thyroxin-binding-globulinemia (hypo-TBG-emia). The diagnosis of primary hypothyroidism was established on the basis of low T4 and high TSH levels in two of the three cases; in the third, with elevated TSH and normal T4 levels at screening, thyroid scintiscan showed an ectopic gland located at the base of the tongue. In the case of hypo-TBG-emia, low T4 and TBG levels were associated with normal TSH values. Some cases of transient hypothyroidism were observed in premature infants.
| Original language | English |
|---|---|
| Pages (from-to) | 181-184 |
| Number of pages | 4 |
| Journal | Journal of Endocrinological Investigation |
| Volume | 3 |
| Publication status | Published - 1980 |
| Externally published | Yes |
Keywords
- Congenital Hypothyroidism
- Female
- Humans
- Hypothyroidism
- Infant, Newborn
- Infant, Newborn, Diseases
- Intellectual Disability
- Male
- Mass Screening
- Pilot Projects
- Thyrotropin
- Thyroxine