Peripheral neuropathy in course of progressive systemic sclerosis. Light and ultrastructural study

Girolamo Di Trapani, Salvatore Mazza, Pasquale David, A Tulli, A La Cara, P Laurienzo

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31 Citations (Scopus)

Abstract

Progressive systemic sclerosis (PSS) is a chronic inflammatory disease of the connective tissue with involvement of the skin and other organs. The disease is characterized by an abnormal accumulation of collagen in all tissues and by microangiopathy. The involvement of the peripheral nervous system during PSS is very unusual and few cases are reported in the literature. A morphological study on the neuropathy associated with sclerodermia has been performed in rare cases. In this paper we demonstrate the role that the vascular lesions have in the pathogenesis of neuropathy during scleroderma. In particular, the primary role of the peripheral microangiopathy during PSS (observed in different clinical cases) is verified.
Original languageEnglish
Pages (from-to)103-110
Number of pages8
JournalActa Neuropathologica
Volume72
Publication statusPublished - 1986

Keywords

  • Female
  • Humans
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Peripheral Nervous System Diseases
  • Scleroderma, Systemic
  • Skin
  • Spinal Nerves
  • Sural Nerve

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