Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers

Francesco Autore; Nicola Piccirillo; Andrea Nozza; Idanna Innocenti; Rossana Putzulu; Patrizia Chiusolo; Federica Sora'; Gina Zini Tanzi; Andrea Bacigalupo; Luca Castagna; Simona Sica; Stefania Bramanti; Luca Laurenti

doi:10.1016/j.bbmt.2019.08.011

Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers

Francesco Autore, Nicola Piccirillo, Andrea Nozza, Idanna Innocenti, Rossana Putzulu, Patrizia Chiusolo, Federica Sora', Gina Zini Tanzi, Andrea Bacigalupo, Luca Castagna, Simona Sica, Stefania Bramanti, Luca Laurenti

IRCCS Istituto Clinico Humanitas - Rozzano (Milano)

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Autologous peripheral blood stem cell transplantation should be considered first-line therapy in young patients with POEMS. The best protocol to collect peripheral blood stem cells remains to be defined, because of the disease rarity and the heterogeneity of published case series. We collected clinical and laboratory data from 25 patients undergoing mobilization, of whom 11 were mobilized using cyclophosphamide (CY) followed by granulocyte colony-stimulating factor (G-CSF) and 14 patients using G-CSF. The incidence of poor mobilization was low and not statistically different between the 2 groups. Both schemes (CY plus G-CSF versus G-CSF alone) were able to harvest a sufficient CD34+ cell dose.

Original language	English
Pages (from-to)	2514-2516
Number of pages	3
Journal	Biology of Blood and Marrow Transplantation
Volume	25
DOIs	https://doi.org/10.1016/j.bbmt.2019.08.011
Publication status	Published - 2019

Keywords

Cyclophosphamide
G-CSF
Mobilizing regimen
POEMS syndrome
Peripheral blood hemopoietic stem cell

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10.1016/j.bbmt.2019.08.011

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Autore, F., Piccirillo, N., Nozza, A., Innocenti, I., Putzulu, R., Chiusolo, P., Sora', F., Zini Tanzi, G., Bacigalupo, A., Castagna, L., Sica, S., Bramanti, S., & Laurenti, L. (2019). Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers. Biology of Blood and Marrow Transplantation, 25, 2514-2516. https://doi.org/10.1016/j.bbmt.2019.08.011

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title = "Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers",

abstract = "Autologous peripheral blood stem cell transplantation should be considered first-line therapy in young patients with POEMS. The best protocol to collect peripheral blood stem cells remains to be defined, because of the disease rarity and the heterogeneity of published case series. We collected clinical and laboratory data from 25 patients undergoing mobilization, of whom 11 were mobilized using cyclophosphamide (CY) followed by granulocyte colony-stimulating factor (G-CSF) and 14 patients using G-CSF. The incidence of poor mobilization was low and not statistically different between the 2 groups. Both schemes (CY plus G-CSF versus G-CSF alone) were able to harvest a sufficient CD34+ cell dose.",

keywords = "Cyclophosphamide, G-CSF, Mobilizing regimen, POEMS syndrome, Peripheral blood hemopoietic stem cell, Cyclophosphamide, G-CSF, Mobilizing regimen, POEMS syndrome, Peripheral blood hemopoietic stem cell",

author = "Francesco Autore and Nicola Piccirillo and Andrea Nozza and Idanna Innocenti and Rossana Putzulu and Patrizia Chiusolo and Federica Sora' and {Zini Tanzi}, Gina and Andrea Bacigalupo and Luca Castagna and Simona Sica and Stefania Bramanti and Luca Laurenti",

year = "2019",

doi = "10.1016/j.bbmt.2019.08.011",

language = "English",

volume = "25",

pages = "2514--2516",

journal = "Biology of Blood and Marrow Transplantation",

issn = "1083-8791",

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Autore, F, Piccirillo, N, Nozza, A, Innocenti, I, Putzulu, R, Chiusolo, P , Sora', F, Zini Tanzi, G, Bacigalupo, A, Castagna, L, Sica, S, Bramanti, S & Laurenti, L 2019, 'Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers', Biology of Blood and Marrow Transplantation, vol. 25, pp. 2514-2516. https://doi.org/10.1016/j.bbmt.2019.08.011

TY - JOUR

T1 - Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers

AU - Autore, Francesco

AU - Piccirillo, Nicola

AU - Nozza, Andrea

AU - Innocenti, Idanna

AU - Putzulu, Rossana

AU - Chiusolo, Patrizia

AU - Sora', Federica

AU - Zini Tanzi, Gina

AU - Bacigalupo, Andrea

AU - Castagna, Luca

AU - Sica, Simona

AU - Bramanti, Stefania

AU - Laurenti, Luca

PY - 2019

Y1 - 2019

N2 - Autologous peripheral blood stem cell transplantation should be considered first-line therapy in young patients with POEMS. The best protocol to collect peripheral blood stem cells remains to be defined, because of the disease rarity and the heterogeneity of published case series. We collected clinical and laboratory data from 25 patients undergoing mobilization, of whom 11 were mobilized using cyclophosphamide (CY) followed by granulocyte colony-stimulating factor (G-CSF) and 14 patients using G-CSF. The incidence of poor mobilization was low and not statistically different between the 2 groups. Both schemes (CY plus G-CSF versus G-CSF alone) were able to harvest a sufficient CD34+ cell dose.

AB - Autologous peripheral blood stem cell transplantation should be considered first-line therapy in young patients with POEMS. The best protocol to collect peripheral blood stem cells remains to be defined, because of the disease rarity and the heterogeneity of published case series. We collected clinical and laboratory data from 25 patients undergoing mobilization, of whom 11 were mobilized using cyclophosphamide (CY) followed by granulocyte colony-stimulating factor (G-CSF) and 14 patients using G-CSF. The incidence of poor mobilization was low and not statistically different between the 2 groups. Both schemes (CY plus G-CSF versus G-CSF alone) were able to harvest a sufficient CD34+ cell dose.

KW - Cyclophosphamide

KW - G-CSF

KW - Mobilizing regimen

KW - POEMS syndrome

KW - Peripheral blood hemopoietic stem cell

KW - Cyclophosphamide

KW - G-CSF

KW - Mobilizing regimen

KW - POEMS syndrome

KW - Peripheral blood hemopoietic stem cell

UR - http://hdl.handle.net/10807/142669

UR - http://www.bbmt.org/issues

U2 - 10.1016/j.bbmt.2019.08.011

DO - 10.1016/j.bbmt.2019.08.011

M3 - Article

SN - 1083-8791

VL - 25

SP - 2514

EP - 2516

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

ER -

Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers

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Keywords

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