Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies.

Claudia Brogna; Marco Luigetti; Giulia Norcia; Sara Scalise; Gloria Ferrantini; Beatrice Berti; Domenico Marco Maurizio Romeo; Raffaele Manna; Eugenio Maria Mercuri; Marika Pane

doi:10.3390/brainsci10030156

Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies.

Claudia Brogna, Marco Luigetti, Giulia Norcia, Sara Scalise, Gloria Ferrantini, Beatrice Berti, Domenico Marco Maurizio Romeo, Raffaele Manna, Eugenio Maria Mercuri, Marika Pane

Research output: Contribution to journal › Meeting Abstract

Abstract

We report the clinical case of a nine-year-old girl who presented with progressive motor neuropathy, revealed via the detection of a higher delay in F-wave recording using digitalized nerve conduction/electromyography. Since the lupus anticoagulant (LAC) positivity, detected using diluted Russell viper venom time (dRVVT), switched to persistent serological anticardiolipin immunoglobulin G (IgG) positivity, a possible non-thrombotic antiphospholipid antibody (aPL)-related clinical manifestation was suspected, and intravenous immunoglobulin treatment (IVIG) was started. The IVIG treatment was well tolerated and the complete resolution of motor impairment was obtained after the third IVIG infusion. Our findings suggest that it could be useful to check for antiphospholipid antibodies in children with a rapid onset of progressive neurological signs in order to provide the beneficial use of IVIG in the treatment of pediatric aPL neurological conditions.

Original language	English
Pages (from-to)	N/A-N/A
Journal	Brain Sciences
DOIs	https://doi.org/10.3390/brainsci10030156
Publication status	Published - 2020

Keywords

neuropathy

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title = "Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies.",

abstract = "We report the clinical case of a nine-year-old girl who presented with progressive motor neuropathy, revealed via the detection of a higher delay in F-wave recording using digitalized nerve conduction/electromyography. Since the lupus anticoagulant (LAC) positivity, detected using diluted Russell viper venom time (dRVVT), switched to persistent serological anticardiolipin immunoglobulin G (IgG) positivity, a possible non-thrombotic antiphospholipid antibody (aPL)-related clinical manifestation was suspected, and intravenous immunoglobulin treatment (IVIG) was started. The IVIG treatment was well tolerated and the complete resolution of motor impairment was obtained after the third IVIG infusion. Our findings suggest that it could be useful to check for antiphospholipid antibodies in children with a rapid onset of progressive neurological signs in order to provide the beneficial use of IVIG in the treatment of pediatric aPL neurological conditions.",

keywords = "neuropathy, neuropathy",

author = "Claudia Brogna and Marco Luigetti and Giulia Norcia and Sara Scalise and Gloria Ferrantini and Beatrice Berti and Romeo, {Domenico Marco Maurizio} and Raffaele Manna and Mercuri, {Eugenio Maria} and Marika Pane",

year = "2020",

doi = "10.3390/brainsci10030156",

language = "English",

pages = "N/A--N/A",

journal = "Brain Sciences",

issn = "2076-3425",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies.

AU - Brogna, Claudia

AU - Luigetti, Marco

AU - Norcia, Giulia

AU - Scalise, Sara

AU - Ferrantini, Gloria

AU - Berti, Beatrice

AU - Romeo, Domenico Marco Maurizio

AU - Manna, Raffaele

AU - Mercuri, Eugenio Maria

AU - Pane, Marika

PY - 2020

Y1 - 2020

N2 - We report the clinical case of a nine-year-old girl who presented with progressive motor neuropathy, revealed via the detection of a higher delay in F-wave recording using digitalized nerve conduction/electromyography. Since the lupus anticoagulant (LAC) positivity, detected using diluted Russell viper venom time (dRVVT), switched to persistent serological anticardiolipin immunoglobulin G (IgG) positivity, a possible non-thrombotic antiphospholipid antibody (aPL)-related clinical manifestation was suspected, and intravenous immunoglobulin treatment (IVIG) was started. The IVIG treatment was well tolerated and the complete resolution of motor impairment was obtained after the third IVIG infusion. Our findings suggest that it could be useful to check for antiphospholipid antibodies in children with a rapid onset of progressive neurological signs in order to provide the beneficial use of IVIG in the treatment of pediatric aPL neurological conditions.

AB - We report the clinical case of a nine-year-old girl who presented with progressive motor neuropathy, revealed via the detection of a higher delay in F-wave recording using digitalized nerve conduction/electromyography. Since the lupus anticoagulant (LAC) positivity, detected using diluted Russell viper venom time (dRVVT), switched to persistent serological anticardiolipin immunoglobulin G (IgG) positivity, a possible non-thrombotic antiphospholipid antibody (aPL)-related clinical manifestation was suspected, and intravenous immunoglobulin treatment (IVIG) was started. The IVIG treatment was well tolerated and the complete resolution of motor impairment was obtained after the third IVIG infusion. Our findings suggest that it could be useful to check for antiphospholipid antibodies in children with a rapid onset of progressive neurological signs in order to provide the beneficial use of IVIG in the treatment of pediatric aPL neurological conditions.

KW - neuropathy

UR - http://hdl.handle.net/10807/151774

U2 - 10.3390/brainsci10030156

DO - 10.3390/brainsci10030156

M3 - Meeting Abstract

SN - 2076-3425

SP - N/A-N/A

JO - Brain Sciences

JF - Brain Sciences

ER -

Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies.

Abstract

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