Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology

Giovanni Gambaro; Antonia Fabris; Cataldo Abaterusso; Alex Cosaro; Monica Ceol; Federica Mezzabotta; Rossella Torregrossa; Emilia Tiralongo; Dorella Del Prete; Angela D'Angelo; Franca Anglani

Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology

Giovanni Gambaro
, Antonia Fabris
, Cataldo Abaterusso
, Alex Cosaro
, Monica Ceol
, Federica Mezzabotta
, Rossella Torregrossa
, Emilia Tiralongo
, Dorella Del Prete
, Angela D'Angelo
, Franca Anglani

Università Cattolica del Sacro Cuore

University of Verona
Azienda Ospedaliera di Padova

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle's loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved.

Original language	English
Pages (from-to)	107-109
Number of pages	3
Journal	Clinical Cases in Mineral and Bone Metabolism
Volume	5
Publication status	Published - 2008

Keywords

Nephrolithiasis

Cite this

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title = "Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology",

abstract = "Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle's loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved.",

keywords = "Nephrolithiasis, Nephrolithiasis",

author = "Giovanni Gambaro and Antonia Fabris and Cataldo Abaterusso and Alex Cosaro and Monica Ceol and Federica Mezzabotta and Rossella Torregrossa and Emilia Tiralongo and \{Del Prete\}, Dorella and Angela D'Angelo and Franca Anglani",

year = "2008",

language = "English",

volume = "5",

pages = "107--109",

journal = "Clinical Cases in Mineral and Bone Metabolism",

issn = "1724-8914",

publisher = "CIC Edizioni Internazionali s.r.l.",

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TY - JOUR

T1 - Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology

AU - Gambaro, Giovanni

AU - Fabris, Antonia

AU - Abaterusso, Cataldo

AU - Cosaro, Alex

AU - Ceol, Monica

AU - Mezzabotta, Federica

AU - Torregrossa, Rossella

AU - Tiralongo, Emilia

AU - Del Prete, Dorella

AU - D'Angelo, Angela

AU - Anglani, Franca

PY - 2008

Y1 - 2008

N2 - Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle's loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved.

AB - Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle's loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved.

KW - Nephrolithiasis

UR - http://hdl.handle.net/10807/23960

M3 - Article

SN - 1724-8914

VL - 5

SP - 107

EP - 109

JO - Clinical Cases in Mineral and Bone Metabolism

JF - Clinical Cases in Mineral and Bone Metabolism

ER -

Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology

Abstract

Keywords

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