Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology

Giovanni Gambaro; Antonia Fabris; Cataldo Abaterusso; Alex Cosaro; Monica Ceol; Federica Mezzabotta; Rossella Torregrossa; Emilia Tiralongo; Dorella Del Prete; Angela D'Angelo; Franca Anglani

Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology

Giovanni Gambaro, Antonia Fabris, Cataldo Abaterusso, Alex Cosaro, Monica Ceol, Federica Mezzabotta, Rossella Torregrossa, Emilia Tiralongo, Dorella Del Prete, Angela D'Angelo, Franca Anglani

Università Cattolica del Sacro Cuore

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle's loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved.

Original language	English
Pages (from-to)	107-109
Number of pages	3
Journal	Clinical Cases in Mineral and Bone Metabolism
Volume	5
Publication status	Published - 2008

Keywords

Nephrolithiasis

Cite this

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title = "Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology",

abstract = "Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle's loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved.",

keywords = "Nephrolithiasis, Nephrolithiasis",

author = "Giovanni Gambaro and Antonia Fabris and Cataldo Abaterusso and Alex Cosaro and Monica Ceol and Federica Mezzabotta and Rossella Torregrossa and Emilia Tiralongo and \{Del Prete\}, Dorella and Angela D'Angelo and Franca Anglani",

year = "2008",

language = "English",

volume = "5",

pages = "107--109",

journal = "Clinical Cases in Mineral and Bone Metabolism",

issn = "1724-8914",

publisher = "CIC Edizioni Internazionali s.r.l.",

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TY - JOUR

T1 - Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology

AU - Gambaro, Giovanni

AU - Fabris, Antonia

AU - Abaterusso, Cataldo

AU - Cosaro, Alex

AU - Ceol, Monica

AU - Mezzabotta, Federica

AU - Torregrossa, Rossella

AU - Tiralongo, Emilia

AU - Del Prete, Dorella

AU - D'Angelo, Angela

AU - Anglani, Franca

PY - 2008

Y1 - 2008

N2 - Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle's loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved.

AB - Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle's loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved.

KW - Nephrolithiasis

UR - http://hdl.handle.net/10807/23960

M3 - Article

SN - 1724-8914

VL - 5

SP - 107

EP - 109

JO - Clinical Cases in Mineral and Bone Metabolism

JF - Clinical Cases in Mineral and Bone Metabolism

ER -

Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology

Abstract

Keywords

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