Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis

Haressh Sajiir; Kuan Yau Wong; Alexandra Müller; Sahar Keshvari; Lucy Burr; Elena Aiello; Teresa Mezza; Andrea Giaccari; Guido Sebastiani; Francesco Dotta; Grant A. Ramm; Graeme A. Macdonald; Michael A. Mcguckin; Johannes B. Prins; Sumaira Z. Hasnain

doi:10.1038/s41467-024-48320-2

Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis

Haressh Sajiir
, Kuan Yau Wong
, Alexandra Müller
, Sahar Keshvari
, Lucy Burr
, Elena Aiello
, Teresa Mezza
, Andrea Giaccari
, Guido Sebastiani
, Francesco Dotta
, Grant A. Ramm
, Graeme A. Macdonald
, Michael A. Mcguckin
, Johannes B. Prins
, Sumaira Z. Hasnain

Research output: Contribution to journal › Article

Abstract

IL-22RA1 is highly expressed on pancreatic islets and absent on immune cells. Here, the authors investigate its role by generating animals that lack IL-22RA1 on beta cells and reveal IL22RA1 signalling is critical for insulin biosynthesis and beta-cell health, evidenced by its regulation of MHC II expression and its suppressive effect on inflammation and cellular stress.

Original language	English
Pages (from-to)	N/A-N/A
Journal	Nature Communications
Volume	15
DOIs	https://doi.org/10.1038/s41467-024-48320-2
Publication status	Published - 2024

Keywords

Glucose Intolerance / metabolism

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10.1038/s41467-024-48320-2

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Sajiir, H., Wong, K. Y., Müller, A., Keshvari, S., Burr, L., Aiello, E., Mezza, T., Giaccari, A., Sebastiani, G., Dotta, F., Ramm, G. A., Macdonald, G. A., Mcguckin, M. A., Prins, J. B., & Hasnain, S. Z. (2024). Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis. Nature Communications, 15, N/A-N/A. https://doi.org/10.1038/s41467-024-48320-2

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title = "Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis",

abstract = "IL-22RA1 is highly expressed on pancreatic islets and absent on immune cells. Here, the authors investigate its role by generating animals that lack IL-22RA1 on beta cells and reveal IL22RA1 signalling is critical for insulin biosynthesis and beta-cell health, evidenced by its regulation of MHC II expression and its suppressive effect on inflammation and cellular stress.",

keywords = "Glucose Intolerance / metabolism, Glucose Intolerance / metabolism",

author = "Haressh Sajiir and Wong, \{Kuan Yau\} and Alexandra M{\"u}ller and Sahar Keshvari and Lucy Burr and Elena Aiello and Teresa Mezza and Andrea Giaccari and Guido Sebastiani and Francesco Dotta and Ramm, \{Grant A.\} and Macdonald, \{Graeme A.\} and Mcguckin, \{Michael A.\} and Prins, \{Johannes B.\} and Hasnain, \{Sumaira Z.\}",

year = "2024",

doi = "10.1038/s41467-024-48320-2",

language = "English",

volume = "15",

pages = "N/A--N/A",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

Sajiir, H, Wong, KY, Müller, A, Keshvari, S, Burr, L, Aiello, E, Mezza, T , Giaccari, A, Sebastiani, G, Dotta, F, Ramm, GA, Macdonald, GA, Mcguckin, MA, Prins, JB & Hasnain, SZ 2024, 'Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis', Nature Communications, vol. 15, pp. N/A-N/A. https://doi.org/10.1038/s41467-024-48320-2

TY - JOUR

T1 - Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis

AU - Sajiir, Haressh

AU - Wong, Kuan Yau

AU - Müller, Alexandra

AU - Keshvari, Sahar

AU - Burr, Lucy

AU - Aiello, Elena

AU - Mezza, Teresa

AU - Giaccari, Andrea

AU - Sebastiani, Guido

AU - Dotta, Francesco

AU - Ramm, Grant A.

AU - Macdonald, Graeme A.

AU - Mcguckin, Michael A.

AU - Prins, Johannes B.

AU - Hasnain, Sumaira Z.

PY - 2024

Y1 - 2024

N2 - IL-22RA1 is highly expressed on pancreatic islets and absent on immune cells. Here, the authors investigate its role by generating animals that lack IL-22RA1 on beta cells and reveal IL22RA1 signalling is critical for insulin biosynthesis and beta-cell health, evidenced by its regulation of MHC II expression and its suppressive effect on inflammation and cellular stress.

AB - IL-22RA1 is highly expressed on pancreatic islets and absent on immune cells. Here, the authors investigate its role by generating animals that lack IL-22RA1 on beta cells and reveal IL22RA1 signalling is critical for insulin biosynthesis and beta-cell health, evidenced by its regulation of MHC II expression and its suppressive effect on inflammation and cellular stress.

KW - Glucose Intolerance / metabolism

UR - http://hdl.handle.net/10807/302095

U2 - 10.1038/s41467-024-48320-2

DO - 10.1038/s41467-024-48320-2

M3 - Article

SN - 2041-1723

VL - 15

SP - N/A-N/A

JO - Nature Communications

JF - Nature Communications

ER -

Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis

Abstract

Keywords

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