Pan-echinocandin-resistant candida glabrata bloodstream infection complicating covid-19: A fatal case report

Brunella Posteraro; Riccardo Torelli; Antonietta Vella; Paolo Maria Leone; Giulia De Angelis; Elena De Carolis; Giulio Ventura; Maurizio Sanguinetti; Massimo Fantoni

doi:10.3390/jof6030163

Pan-echinocandin-resistant candida glabrata bloodstream infection complicating covid-19: A fatal case report

Brunella Posteraro, Riccardo Torelli, Antonietta Vella, Paolo Maria Leone, Giulia De Angelis, Elena De Carolis, Giulio Ventura, Maurizio Sanguinetti, Massimo Fantoni

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

Coinfections with bacteria or fungi may be a frequent complication of COVID-19, but coinfections with Candida species in COVID-19 patients remain rare. We report the 53-day clinical course of a complicated type-2 diabetes patient diagnosed with COVID-19, who developed bloodstream infections initially due to methicillin-resistant Staphylococcus aureus, secondly due to multidrug-resistant Gram-negative bacteria, and lastly due to a possibly fatal Candida glabrata. The development of FKS-associated pan-echinocandin resistance in the C. glabrata isolated from the patient after 13 days of caspofungin treatment aggravated the situation. The patient died of septic shock shortly before the prospect of receiving potentially effective antifungal therapy. This case emphasizes the importance of early diagnosis and monitoring for antimicrobial drug-resistant coinfections to reduce their unfavorable outcomes in COVID-19 patients.

Original language	English
Pages (from-to)	1-11
Number of pages	11
Journal	Journal of Fungi
Volume	6
DOIs	https://doi.org/10.3390/jof6030163
Publication status	Published - 2020

Keywords

Bloodstream infection
Candida glabrata
Coinfection
Diabetes
Echinocandin resistance
FKS mutation
SARS-CoV-2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/jof6030163

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title = "Pan-echinocandin-resistant candida glabrata bloodstream infection complicating covid-19: A fatal case report",

abstract = "Coinfections with bacteria or fungi may be a frequent complication of COVID-19, but coinfections with Candida species in COVID-19 patients remain rare. We report the 53-day clinical course of a complicated type-2 diabetes patient diagnosed with COVID-19, who developed bloodstream infections initially due to methicillin-resistant Staphylococcus aureus, secondly due to multidrug-resistant Gram-negative bacteria, and lastly due to a possibly fatal Candida glabrata. The development of FKS-associated pan-echinocandin resistance in the C. glabrata isolated from the patient after 13 days of caspofungin treatment aggravated the situation. The patient died of septic shock shortly before the prospect of receiving potentially effective antifungal therapy. This case emphasizes the importance of early diagnosis and monitoring for antimicrobial drug-resistant coinfections to reduce their unfavorable outcomes in COVID-19 patients.",

keywords = "Bloodstream infection, Candida glabrata, Coinfection, Diabetes, Echinocandin resistance, FKS mutation, SARS-CoV-2, Bloodstream infection, Candida glabrata, Coinfection, Diabetes, Echinocandin resistance, FKS mutation, SARS-CoV-2",

author = "Brunella Posteraro and Riccardo Torelli and Antonietta Vella and Leone, {Paolo Maria} and {De Angelis}, Giulia and {De Carolis}, Elena and Giulio Ventura and Maurizio Sanguinetti and Massimo Fantoni",

year = "2020",

doi = "10.3390/jof6030163",

language = "English",

volume = "6",

pages = "1--11",

journal = "Journal of Fungi",

issn = "2309-608X",

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T1 - Pan-echinocandin-resistant candida glabrata bloodstream infection complicating covid-19: A fatal case report

AU - Posteraro, Brunella

AU - Torelli, Riccardo

AU - Vella, Antonietta

AU - Leone, Paolo Maria

AU - De Angelis, Giulia

AU - De Carolis, Elena

AU - Ventura, Giulio

AU - Sanguinetti, Maurizio

AU - Fantoni, Massimo

PY - 2020

Y1 - 2020

N2 - Coinfections with bacteria or fungi may be a frequent complication of COVID-19, but coinfections with Candida species in COVID-19 patients remain rare. We report the 53-day clinical course of a complicated type-2 diabetes patient diagnosed with COVID-19, who developed bloodstream infections initially due to methicillin-resistant Staphylococcus aureus, secondly due to multidrug-resistant Gram-negative bacteria, and lastly due to a possibly fatal Candida glabrata. The development of FKS-associated pan-echinocandin resistance in the C. glabrata isolated from the patient after 13 days of caspofungin treatment aggravated the situation. The patient died of septic shock shortly before the prospect of receiving potentially effective antifungal therapy. This case emphasizes the importance of early diagnosis and monitoring for antimicrobial drug-resistant coinfections to reduce their unfavorable outcomes in COVID-19 patients.

AB - Coinfections with bacteria or fungi may be a frequent complication of COVID-19, but coinfections with Candida species in COVID-19 patients remain rare. We report the 53-day clinical course of a complicated type-2 diabetes patient diagnosed with COVID-19, who developed bloodstream infections initially due to methicillin-resistant Staphylococcus aureus, secondly due to multidrug-resistant Gram-negative bacteria, and lastly due to a possibly fatal Candida glabrata. The development of FKS-associated pan-echinocandin resistance in the C. glabrata isolated from the patient after 13 days of caspofungin treatment aggravated the situation. The patient died of septic shock shortly before the prospect of receiving potentially effective antifungal therapy. This case emphasizes the importance of early diagnosis and monitoring for antimicrobial drug-resistant coinfections to reduce their unfavorable outcomes in COVID-19 patients.

KW - Bloodstream infection

KW - Candida glabrata

KW - Coinfection

KW - Diabetes

KW - Echinocandin resistance

KW - FKS mutation

KW - SARS-CoV-2

KW - Bloodstream infection

KW - Candida glabrata

KW - Coinfection

KW - Diabetes

KW - Echinocandin resistance

KW - FKS mutation

KW - SARS-CoV-2

UR - http://hdl.handle.net/10807/166922

U2 - 10.3390/jof6030163

DO - 10.3390/jof6030163

M3 - Article

SN - 2309-608X

VL - 6

SP - 1

EP - 11

JO - Journal of Fungi

JF - Journal of Fungi

ER -

Pan-echinocandin-resistant candida glabrata bloodstream infection complicating covid-19: A fatal case report

Abstract

Keywords

UN SDGs

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