Oxidative Stress And Overexpression Of Manganese Superoxide Dismutase In Patients With Alzheimer's Disease.

Me De Leo; Silvia Borrello; M Passantino; B Palazzotti; Alvaro Mordente; Antonio Daniele; V Filippini; Tommaso Galeotti; Carlo Masullo

Oxidative Stress And Overexpression Of Manganese Superoxide Dismutase In Patients With Alzheimer's Disease.

Me De Leo, Silvia Borrello, M Passantino, B Palazzotti, Alvaro Mordente, Antonio Daniele, V Filippini, Tommaso Galeotti, Carlo Masullo

Research output: Contribution to journal › Article › peer-review

97 Citations (Scopus)

Abstract

Substantial evidence supports the hypothesis that oxygen free radicals are involved in various neurodegenerative disorders. To assess the presence of oxidative stress in Alzheimer's disease (AD) we examined the activity of the enzyme copper-zinc superoxide dismutase (CuZnSOD) in red blood cells, the levels of the mitochondrial inducible enzyme manganese superoxide dismutase (MnSOD) mRNA in lymphocytes, and the total radical-trapping antioxidant capacity (TRAP) in plasma of AD patients and in a group of age-matched non-demented controls. We found that CuZnSOD activity (P < 0.01 vs. controls) was significantly increased as well as the MnSOD mRNA levels while the total antioxidant status (P < 0.001 vs. controls) was decreased in AD patients. These findings support the role of oxidative alterations in the pathogenetic mechanism underlying AD neurodegeneration.

Original language	English
Pages (from-to)	173-176
Number of pages	4
Journal	Neuroscience Letters
Publication status	Published - 1998

Keywords

SUPEROSSIDE DISMUTASE
oxidative stress

Cite this

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title = "Oxidative Stress And Overexpression Of Manganese Superoxide Dismutase In Patients With Alzheimer's Disease.",

abstract = "Substantial evidence supports the hypothesis that oxygen free radicals are involved in various neurodegenerative disorders. To assess the presence of oxidative stress in Alzheimer's disease (AD) we examined the activity of the enzyme copper-zinc superoxide dismutase (CuZnSOD) in red blood cells, the levels of the mitochondrial inducible enzyme manganese superoxide dismutase (MnSOD) mRNA in lymphocytes, and the total radical-trapping antioxidant capacity (TRAP) in plasma of AD patients and in a group of age-matched non-demented controls. We found that CuZnSOD activity (P < 0.01 vs. controls) was significantly increased as well as the MnSOD mRNA levels while the total antioxidant status (P < 0.001 vs. controls) was decreased in AD patients. These findings support the role of oxidative alterations in the pathogenetic mechanism underlying AD neurodegeneration.",

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T1 - Oxidative Stress And Overexpression Of Manganese Superoxide Dismutase In Patients With Alzheimer's Disease.

AU - De Leo, Me

AU - Borrello, Silvia

AU - Passantino, M

AU - Palazzotti, B

AU - Mordente, Alvaro

AU - Daniele, Antonio

AU - Filippini, V

AU - Galeotti, Tommaso

AU - Masullo, Carlo

PY - 1998

Y1 - 1998

N2 - Substantial evidence supports the hypothesis that oxygen free radicals are involved in various neurodegenerative disorders. To assess the presence of oxidative stress in Alzheimer's disease (AD) we examined the activity of the enzyme copper-zinc superoxide dismutase (CuZnSOD) in red blood cells, the levels of the mitochondrial inducible enzyme manganese superoxide dismutase (MnSOD) mRNA in lymphocytes, and the total radical-trapping antioxidant capacity (TRAP) in plasma of AD patients and in a group of age-matched non-demented controls. We found that CuZnSOD activity (P < 0.01 vs. controls) was significantly increased as well as the MnSOD mRNA levels while the total antioxidant status (P < 0.001 vs. controls) was decreased in AD patients. These findings support the role of oxidative alterations in the pathogenetic mechanism underlying AD neurodegeneration.

AB - Substantial evidence supports the hypothesis that oxygen free radicals are involved in various neurodegenerative disorders. To assess the presence of oxidative stress in Alzheimer's disease (AD) we examined the activity of the enzyme copper-zinc superoxide dismutase (CuZnSOD) in red blood cells, the levels of the mitochondrial inducible enzyme manganese superoxide dismutase (MnSOD) mRNA in lymphocytes, and the total radical-trapping antioxidant capacity (TRAP) in plasma of AD patients and in a group of age-matched non-demented controls. We found that CuZnSOD activity (P < 0.01 vs. controls) was significantly increased as well as the MnSOD mRNA levels while the total antioxidant status (P < 0.001 vs. controls) was decreased in AD patients. These findings support the role of oxidative alterations in the pathogenetic mechanism underlying AD neurodegeneration.

KW - SUPEROSSIDE DISMUTASE

KW - oxidative stress

KW - SUPEROSSIDE DISMUTASE

KW - oxidative stress

UR - http://hdl.handle.net/10807/9301

M3 - Article

SN - 0304-3940

SP - 173

EP - 176

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

Oxidative Stress And Overexpression Of Manganese Superoxide Dismutase In Patients With Alzheimer's Disease.

Abstract

Keywords

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