Oxidation of [1,12-14C]dodecanedioic acid by rat pancreatic islets

Wj Malaisse, Av Greco, Geltrude Mingrone

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Several aliphatic dioic acids were recently reported to stimulate insulin release in isolated rat pancreatic islets incubated at close-to-physiological D-glucose concentrations. In order to gain insight into the mode of action of these acids in pancreatic islet B-cells, the oxidation of [1,12-14C]dodecanedioic acid (5.0 mM) was now measured in rat islets. Expressed as pmol of [1, 12-14C]dodecanedioic acid equivalent, the production of 14CO2 was close to 1.0 pmol/islet per 120 min, representing about 8% of that attributable to the oxidation of D-[U-14C]-glucose (8.3 mM). The dioic acid and the hexose failed to exert any significant reciprocal effect upon their respective oxidation rate. These findings support the view that the insulinotropic action of dodecanedioic acid, and presumably other aliphatic dioic acids, is causally linked to their capacity to act as nutrients in pancreatic islet cells.
Original languageEnglish
Pages (from-to)453-454
Number of pages2
JournalInternational Journal of Molecular Medicine
Volume6
Publication statusPublished - 2000

Keywords

  • Animals
  • Carbon Dioxide
  • Carbon Radioisotopes
  • Dicarboxylic Acids
  • Female
  • Glucose
  • Islets of Langerhans
  • Oxidation-Reduction
  • Rats
  • Rats, Wistar

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