Oral lichenoid lesions in HIV-HCV-coinfected subjects during antiviral therapy: 2 cases and review of the literature

Carlo Lajolo, Mario Tumbarello, Michele Giuliani, Alessandra Sartorio, Michele Scivetti, Saverio Capodiferro

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Some dental materials and certain drugs may induce epithelial alterations, which clinically resemble oral lichen planus (OLP), on oral mucosa. But these alterations do not have all the clinical and/or the histological features of OLP; these lesions are known as oral lichenoid lesions (OLLs). Some researchers describe the onset and/or the worsening of OLL/OLP after the administration of anti-hepatitis C virus (HCV) therapy. In this article, we describe the development of symptomatic OLLs, as a consequence of anti-HCV therapy (interferon-alpha and ribavirine), in 2 human immunodeficiency virus-HCV-coinfected subjects. An immunological cause related to coinfection and administration of different medications could be responsible for the onset of OLLs. These new cases, together with the previous reports of a possible association between OLP and/or OLL and anti-HCV therapy, highlight the absolute need to monitor carefully the human immunodeficiency virus-HCV-coinfected subjects who are about to start the anti-HCV therapy and to define better the clinical and histopathological criteria to distinguish OLP from OLL.
Original languageEnglish
Pages (from-to)466-471
Number of pages6
JournalAmerican Journal of Dermatopathology
Volume2008
Publication statusPublished - 2008

Keywords

  • HAART
  • HCV
  • HIV
  • lichenoid
  • oral lesions

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