Oral hyposensitization to nickel allergy: preliminary clinical results

Eleonora Nucera, Domenico Schiavino, Stefano Pellegrino, Giampiero Patriarca, Rc Panzani, G Fais, G Schinco

Research output: Contribution to journalArticle

42 Citations (Scopus)


Fifty-one patients presenting a dermatological allergy (erythema, urticaria, angioedema, contact dermatitis) to nickel were treated over 3 years with oral doses of 0.1 ng nickel sulfate per day, following a low-nickel diet. Diagnostic tests comprised patch and oral provocation tests. In 7 cases, the treatment was interrupted because of symptom reactivation, and in 14 cases for other reasons. Among the 30 cases who went through the whole follow-up, symptomatology totally disappeared in 29 cases, and a partial alleviation was achieved in 1 case after 1 year of treatment. Oral provocation tests with these 30 patients showed an overall increase of tolerance. Patch tests showed no variation in 20 cases, a diminution in 5, and were negative in 5. Although the study was not conducted double blind, the results of this attempt to cure nickel allergy are statistically significant.
Original languageEnglish
Pages (from-to)251-254
Number of pages4
JournalInternational Archives of Allergy and Immunology
Publication statusPublished - 1995


  • Administration, Oral
  • Adolescent
  • Adult
  • Combined Modality Therapy
  • Desensitization, Immunologic
  • Diet
  • Drug Eruptions
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nickel
  • Patch Tests
  • Treatment Outcome


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