Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)

Giorgio Walter Canonica; Francesco Blasi; Pierluigi Paggiaro; Gianenrico Senna; Giovanni Passalacqua; Antonio Spanevello; Stefano Aliberti; Diego Bagnasco; Marco Bonavia; Matteo Bonini; Luisa Brussino; Caterina Bucca; Maria F. Caiaffa; Cecilia Calabrese; Anna Chiara Calabrese; Gianna Camiciottoli; Marco Caminati; Giovanna E. Carpagnano; Corrado Maria Roberto Caruso; Stefano Centanni; Maria E. Conte; Angelo G. Corsico; Lorenzo Cosmi; Maria T. Costantino; Nunzio Crimi; Simona D'Alò; Maria D'Amato; Stefano Del Giacco; Alessandro Farsi; Elisabetta Favero; Maria P. Foschino Barbaro; Gabriella Guarnieri; Giuseppe Guida; Maria Grazia Guida; Manuela Latorre; Salvatore Lo Cicero; Stefano Lo Cicero; Carlo Lombardi; Celestino Pio Lombardi; Luigi Macchia; Francesco Mazza; Francesco Menzella; Manlio Milanese; Marcello Montagni; Paolo Montuschi; Eleonora Nucera; Roberta Parente; Vincenzo Patella; Girolamo Pelaia; Laura Pini; Francesca Puggioni; Luisa Ricciardi; Fabio L.M. Ricciardolo; Luca Richeldi; Erminia Ridolo; Giovanni Rolla; Pierachille Santus; Nicola Scichilone; Giuseppe Spadaro; Andrea Vianello; Vittorio Viviano; Mona R. Yacoub; Maria C. Zappa; Enrico Heffler

doi:10.1016/j.waojou.2020.100464

Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)

Giorgio Walter Canonica, Francesco Blasi, Pierluigi Paggiaro, Gianenrico Senna, Giovanni Passalacqua, Antonio Spanevello, Stefano Aliberti, Diego Bagnasco, Marco Bonavia, Matteo Bonini, Luisa Brussino, Caterina Bucca, Maria F. Caiaffa, Cecilia Calabrese, Anna Chiara Calabrese, Gianna Camiciottoli, Marco Caminati, Giovanna E. Carpagnano, Corrado Maria Roberto Caruso, Stefano CentanniMaria E. Conte, Angelo G. Corsico, Lorenzo Cosmi, Maria T. Costantino, Nunzio Crimi, Simona D'Alò, Maria D'Amato, Stefano Del Giacco, Alessandro Farsi, Elisabetta Favero, Maria P. Foschino Barbaro, Gabriella Guarnieri, Giuseppe Guida, Maria Grazia Guida, Manuela Latorre, Salvatore Lo Cicero, Stefano Lo Cicero, Carlo Lombardi, Celestino Pio Lombardi, Luigi Macchia, Francesco Mazza, Francesco Menzella, Manlio Milanese, Marcello Montagni, Paolo Montuschi, Eleonora Nucera, Roberta Parente, Vincenzo Patella, Girolamo Pelaia, Laura Pini, Francesca Puggioni, Luisa Ricciardi, Fabio L.M. Ricciardolo, Luca Richeldi, Erminia Ridolo, Giovanni Rolla, Pierachille Santus, Nicola Scichilone, Giuseppe Spadaro, Andrea Vianello, Vittorio Viviano, Mona R. Yacoub, Maria C. Zappa, Enrico Heffler

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Abstract

According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored all alternatives currently available for a large part of severe asthmatics.

Original language	English
Pages (from-to)	N/A-N/A
Journal	THE WORLD ALLERGY ORGANIZATION JOURNAL
Volume	13
DOIs	https://doi.org/10.1016/j.waojou.2020.100464
Publication status	Published - 2020

Keywords

Biologics
Oral corticosteroids
Real-life
Registr
Severe asthma

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10.1016/j.waojou.2020.100464

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Canonica, G. W., Blasi, F., Paggiaro, P., Senna, G., Passalacqua, G., Spanevello, A., Aliberti, S., Bagnasco, D., Bonavia, M., Bonini, M., Brussino, L., Bucca, C., Caiaffa, M. F., Calabrese, C., Calabrese, A. C., Camiciottoli, G., Caminati, M., Carpagnano, G. E., Caruso, C. M. R., ... Heffler, E. (2020). Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI). THE WORLD ALLERGY ORGANIZATION JOURNAL, 13, N/A-N/A. https://doi.org/10.1016/j.waojou.2020.100464

@article{b465c25ba70c4f059bcdb1b54c4dfac5,

title = "Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)",

abstract = "According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored all alternatives currently available for a large part of severe asthmatics.",

keywords = "Biologics, Oral corticosteroids, Real-life, Registr, Severe asthma, Biologics, Oral corticosteroids, Real-life, Registr, Severe asthma",

author = "Canonica, {Giorgio Walter} and Francesco Blasi and Pierluigi Paggiaro and Gianenrico Senna and Giovanni Passalacqua and Antonio Spanevello and Stefano Aliberti and Diego Bagnasco and Marco Bonavia and Matteo Bonini and Luisa Brussino and Caterina Bucca and Caiaffa, {Maria F.} and Cecilia Calabrese and Calabrese, {Anna Chiara} and Gianna Camiciottoli and Marco Caminati and Carpagnano, {Giovanna E.} and Caruso, {Corrado Maria Roberto} and Stefano Centanni and Conte, {Maria E.} and Corsico, {Angelo G.} and Lorenzo Cosmi and Costantino, {Maria T.} and Nunzio Crimi and Simona D'Al{\`o} and Maria D'Amato and {Del Giacco}, Stefano and Alessandro Farsi and Elisabetta Favero and {Foschino Barbaro}, {Maria P.} and Gabriella Guarnieri and Giuseppe Guida and Guida, {Maria Grazia} and Manuela Latorre and {Lo Cicero}, Salvatore and {Lo Cicero}, Stefano and Carlo Lombardi and Lombardi, {Celestino Pio} and Luigi Macchia and Francesco Mazza and Francesco Menzella and Manlio Milanese and Marcello Montagni and Paolo Montuschi and Eleonora Nucera and Roberta Parente and Vincenzo Patella and Girolamo Pelaia and Laura Pini and Francesca Puggioni and Luisa Ricciardi and Ricciardolo, {Fabio L.M.} and Luca Richeldi and Erminia Ridolo and Giovanni Rolla and Pierachille Santus and Nicola Scichilone and Giuseppe Spadaro and Andrea Vianello and Vittorio Viviano and Yacoub, {Mona R.} and Zappa, {Maria C.} and Enrico Heffler",

year = "2020",

doi = "10.1016/j.waojou.2020.100464",

language = "English",

volume = "13",

pages = "N/A--N/A",

journal = "THE WORLD ALLERGY ORGANIZATION JOURNAL",

issn = "1939-4551",

publisher = "Philadelphia, PA : Lippincott Williams & Wilkins",

}

Canonica, GW, Blasi, F, Paggiaro, P, Senna, G, Passalacqua, G, Spanevello, A, Aliberti, S, Bagnasco, D, Bonavia, M, Bonini, M, Brussino, L, Bucca, C, Caiaffa, MF, Calabrese, C, Calabrese, AC, Camiciottoli, G, Caminati, M, Carpagnano, GE, Caruso, CMR, Centanni, S, Conte, ME, Corsico, AG, Cosmi, L, Costantino, MT, Crimi, N, D'Alò, S, D'Amato, M, Del Giacco, S, Farsi, A, Favero, E, Foschino Barbaro, MP, Guarnieri, G, Guida, G, Guida, MG, Latorre, M, Lo Cicero, S, Lo Cicero, S, Lombardi, C, Lombardi, CP, Macchia, L, Mazza, F, Menzella, F, Milanese, M, Montagni, M, Montuschi, P, Nucera, E, Parente, R, Patella, V, Pelaia, G, Pini, L, Puggioni, F, Ricciardi, L, Ricciardolo, FLM, Richeldi, L, Ridolo, E, Rolla, G, Santus, P, Scichilone, N, Spadaro, G, Vianello, A, Viviano, V, Yacoub, MR, Zappa, MC & Heffler, E 2020, 'Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)', THE WORLD ALLERGY ORGANIZATION JOURNAL, vol. 13, pp. N/A-N/A. https://doi.org/10.1016/j.waojou.2020.100464

TY - JOUR

T1 - Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)

AU - Canonica, Giorgio Walter

AU - Blasi, Francesco

AU - Paggiaro, Pierluigi

AU - Senna, Gianenrico

AU - Passalacqua, Giovanni

AU - Spanevello, Antonio

AU - Aliberti, Stefano

AU - Bagnasco, Diego

AU - Bonavia, Marco

AU - Bonini, Matteo

AU - Brussino, Luisa

AU - Bucca, Caterina

AU - Caiaffa, Maria F.

AU - Calabrese, Cecilia

AU - Calabrese, Anna Chiara

AU - Camiciottoli, Gianna

AU - Caminati, Marco

AU - Carpagnano, Giovanna E.

AU - Caruso, Corrado Maria Roberto

AU - Centanni, Stefano

AU - Conte, Maria E.

AU - Corsico, Angelo G.

AU - Cosmi, Lorenzo

AU - Costantino, Maria T.

AU - Crimi, Nunzio

AU - D'Alò, Simona

AU - D'Amato, Maria

AU - Del Giacco, Stefano

AU - Farsi, Alessandro

AU - Favero, Elisabetta

AU - Foschino Barbaro, Maria P.

AU - Guarnieri, Gabriella

AU - Guida, Giuseppe

AU - Guida, Maria Grazia

AU - Latorre, Manuela

AU - Lo Cicero, Salvatore

AU - Lo Cicero, Stefano

AU - Lombardi, Carlo

AU - Lombardi, Celestino Pio

AU - Macchia, Luigi

AU - Mazza, Francesco

AU - Menzella, Francesco

AU - Milanese, Manlio

AU - Montagni, Marcello

AU - Montuschi, Paolo

AU - Nucera, Eleonora

AU - Parente, Roberta

AU - Patella, Vincenzo

AU - Pelaia, Girolamo

AU - Pini, Laura

AU - Puggioni, Francesca

AU - Ricciardi, Luisa

AU - Ricciardolo, Fabio L.M.

AU - Richeldi, Luca

AU - Ridolo, Erminia

AU - Rolla, Giovanni

AU - Santus, Pierachille

AU - Scichilone, Nicola

AU - Spadaro, Giuseppe

AU - Vianello, Andrea

AU - Viviano, Vittorio

AU - Yacoub, Mona R.

AU - Zappa, Maria C.

AU - Heffler, Enrico

PY - 2020

Y1 - 2020

N2 - According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored all alternatives currently available for a large part of severe asthmatics.

AB - According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored all alternatives currently available for a large part of severe asthmatics.

KW - Biologics

KW - Oral corticosteroids

KW - Real-life

KW - Registr

KW - Severe asthma

KW - Biologics

KW - Oral corticosteroids

KW - Real-life

KW - Registr

KW - Severe asthma

UR - http://hdl.handle.net/10807/163501

U2 - 10.1016/j.waojou.2020.100464

DO - 10.1016/j.waojou.2020.100464

M3 - Article

SN - 1939-4551

VL - 13

SP - N/A-N/A

JO - THE WORLD ALLERGY ORGANIZATION JOURNAL

JF - THE WORLD ALLERGY ORGANIZATION JOURNAL

ER -

Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)

Abstract

Keywords

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