Ophthalmia neonatorum: what kind of prophylaxis?

Antonio Alberto Zuppa, Vito D'Andrea, Piero Catenazzi, Antonio Scorrano, Costantino Romagnoli

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

OBJECTIVE: Conjunctivitis during neonatal period occurs in 1-12% of all babies. Ophthalmia neonatorum is an acute muco-purulent conjunctivitis occurring in the first month of birth. It is essentially an infection acquired during vaginal delivery. The most frequent infectious agents involved in ophthalmia neonatorum are Chlamydia trachomatis and Neisseria gonorrhoeae. METHODS: Topical ocular prophylaxis must be instituted early after birth. Recommended prophylactic regimen are: 1% nitrate solution; 1% tetracycline solution; 1% erythromycin solution; 2.5% povidone-iodine solution; and fusidic acid. RESULTS: Evidence suggests better outcomes using 1% tetracycline solutions even if there is the risk of selecting drug resistant bacteria. However, even the widespread used nitrate solution can cause a chemical conjunctivitis, arguing against its widespread use. CONCLUSIONS: Fusidic acid is a relatively new promising therapy even if there are still few data about its use. None of the used regimens has the optimal risk-benefit profile to suggest a widespread use.
Original languageEnglish
Pages (from-to)769-773
Number of pages5
JournalTHE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Publication statusPublished - 2011

Keywords

  • OPHTALMIA NEONATORUM
  • PROPHYLAXIS

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